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- Table of Contents
TIMP2 Antibodies
AND TIMP2 ELISA kits, TIMP2 Proteins
Many biological assays use antibodies to detect TIMP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TIMP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TIMP2 antibodies...
Designing a Western blot for TIMP2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TIMP2 Western Blot GuideDesigning an IHC experiment for TIMP2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the TIMP2 IHC GuideTIMP2 Infographic by Boster Bio
All TIMP2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IHC
$370
Cat # PA1076
100 μg/vial
Cat # PA1076
100 μg/vial
Human
ELISA
$499
Cat # FEK0522
96 wells/kit, with removable strips.
Cat # FEK0522
96 wells/kit, with removable strips.
TIMP2 Overview
Facts about Metalloproteinase inhibitor 2.
Metalloproteinase inhibitor 2 (TIMP2)
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | TIMP2 |
| Uniprot: | P16035 |
| Entrez: | 7077 |
Family
| Belongs to: |
|---|
| protease inhibitor I35 (TIMP) family |
Alternative Names
CSC-21Ktissue inhibitor of metalloproteinase 2; metalloproteinase inhibitor 2; TIMP metallopeptidase inhibitor 2; TIMP2; TIMP-2; Tissue inhibitor of metalloproteinases 2
Molecular Weight
Mass (kDA):
24.399 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q25.3 |
| Sequence: | 17; NC_000017.11 (78852977..78925387, complement) |
Subcellular Localizations
Secreted.
Diseases
- Neoplasms
- Malignant Neoplasms
- Cell Invasion
- Neoplasm Metastasis
- Carcinoma
- Neoplasm Invasiveness
- Fibrosis
- Tumor Angiogenesis
- Malignant Paraganglionic Neoplasm
- Inflammation
- Tissue Adhesions
- Pathologic Neovascularization
Interacting Proteins
- MMP14
- MMP2
Pathways
- Angiogenesis
- Pathogenesis
- Localization
- Cell Migration
- Cell Proliferation
- Secretion
- Tissue Remodeling
- Proteolysis
- Reverse Transcription
- Cell Adhesion
- Methylation
- Cell Growth
- Cell Motility
PTMs
- Phosphorylation
- Cleavage
- Methylation
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TIMP2
bosterbio.com/bosterbio-gene-info-cards/TIMP2
References
PMID: 2380196 by Stetler-Stevenson W.G., et al. Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues.
PMID: 2157214 by Boone T.C., et al. cDNA cloning and expression of a metalloproteinase inhibitor related to tissue inhibitor of metalloproteinases.
33 Publications of Boster TIMP2 Antibodies & ELISA Kits
- PubMed ID: 10.3233/CH-151928, Gelatinases and their tissue inhibitors in a group of subjects with obstructive ...
- PubMed ID: 10.3233/CH-141863, Behaviour of the plasma concentration of gelatinases and their tissue inhibitors...
- PubMed ID: 10.2310/JIM.0b013e318294e9da, Gelatinases and Their Tissue Inhibitors in a Group of Subjects With Metabolic Sy...
- PubMed ID: 10.2147/CMAR.S233776, MMP-2, MMP-9, TIMP-1, and TIMP-2 in the Peripheral Blood of Patients with Differ...
- PubMed ID: 10.1007/s11255-017-1654-3, High glucose stimulates cell proliferation and Collagen IV production in rat mes...
- PubMed ID: 10.1007/s10072-021-05314-y, Expression pattern of matrix metalloproteinases-2 and -9 and their tissue inhibi...
- PubMed ID: 10.1007/s00296-011-2095-4, Implication of MMP-9 and urokinase plasminogen activator (uPA) in the activation...
- PubMed ID: 33988800, Cosentino G,Di Stefano V,Presti RL,Montana M,Todisco M,Gastaldi M,Cortese A,Alfo...
- PubMed ID: 33649809, Nie L,Liu M,Chen J,Wu Q,Li Y,Yi J,Zheng X,Zhang J,Chu C,Yang J.Hydrogen sulfide ...
- PubMed ID: 26196122, Inhibition of pulmonary adenoma in diethylnitrosamine-induced rats by Rhizoma pa...
- PubMed ID: 28260896, Long-term intravenous administration of carboxylated single-walled carbon nanotu...
- PubMed ID: 27575818, Effect of Novel Gasotransmitter hydrogen sulfide on renal fibrosis and connexins...
- PubMed ID: 20688607, Effect of norcantharidin on proliferation and invasion of human gallbladder carc...
- PubMed ID: 29393353, Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK...
- PubMed ID: 27453531, The inhibition of calpains ameliorates vascular restenosis through MMP2/TGF-?1 p...
- PubMed ID: 27340562, Inhibition of Zymosan-Induced Inflammatory Factors Expression by ATRA Nanostruct...
- PubMed ID: 26870168, MMP-1/2 and TIMP-1/2 expression levels, and the levels of collagenous and elasti...
- PubMed ID: 26126526, Acute exacerbations of COPD are associated with significant activation of matrix...
- PubMed ID: 28748494, Zhang, B., Shi, Y.Q., Zou, J.J., Chen, X.F., Tang, W., Ye, F., & Liu, Z.M. (2017...
- PubMed ID: 24427326, Wu Ty, Zhang Th, Qu Lm, Feng Jp, Tian Ll, Zhang Bh, Li Dd, Sun Yn, Liu M. Int J ...
- PubMed ID: 21501651, Qiu Lb, Zhou Y, Wang Q, Yang Ll, Liu Hq, Xu Sl, Qi Yh, Ding Gr, Guo Gz. Toxicolo...
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page