A2ML1 Antibodies

AND A2ML1 ELISA kits, A2ML1 Proteins

Many biological assays use antibodies to detect A2ML1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with A2ML1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop A2ML1 antibodies...

We validate the specificity of these antibodies to A2ML1 by testing them on tissues known to express A2ML1 positively and negatively. Browse below to find the A2ML1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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A2ML1 Infographic by Boster Bio

All A2ML1 Products

Product

Figures

Specificity

Applications

Price

A2ML1 (NM_144670) Human Over-expression Lysate

Human

$960
Cat # LS144568
100 µg

A2ML1 Overview

Facts about Alpha-2-macroglobulin-like protein 1.

A2ML1 3D structure. Source: alphafold

Alpha-2-macroglobulin-like protein 1 (A2ML1)

Is able to inhibit all four classes of proteinases by a unique'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases.

When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced).

Gene Information

Human
Gene Name:	A2ML1
Uniprot:	A8K2U0
Entrez:	144568

Family

Belongs to:

protease inhibitor I39 (alpha-2-macroglobulin) family

Alternative Names

A2ML1; alpha 2Macroglobulin like 1; alpha 2-Macroglobulin-like 1; alpha-2-macroglobulin-like 1; alpha-2-macroglobulin-like protein 1; C3 and PZP-like, alpha-2-macroglobulin domain containing 9; CPAMD9

Molecular Weight

Mass (kDA):
161.107 kDA

Genomic Context


Human

Location:	12p13.31
Sequence:	12; NC_000012.12 (8822554..8887202)

Tissue Specificity

In the epidermis, expressed predominantly in the granular layer at the apical edge of keratinocytes (at protein level). Also detected in placenta, testis and thymus but not in epithelia of kidney, lung, small intestine or colon.