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- Table of Contents
Facts about Tyrosine-protein kinase ABL2.
Binds straight F-actin and regulates actin cytoskeletal structure through its F-actin- bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes like CRK, CRKL, DOK1 or ARHGAP35.
Human | |
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Gene Name: | ABL2 |
Uniprot: | P42684 |
Entrez: | 27 |
Belongs to: |
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protein kinase superfamily |
Abelson murine leukemia viral (v-abl) oncogene homolog 2; Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; Abelson-relatedgene); arg tyrosine kinase; EC 2.7.10; EC 2.7.10.2; FLJ22224; FLJ31718; FLJ41441; tyrosine-protein kinase ABL2; Tyrosine-protein kinase ARG; v-abl Abelson murine leukemia viral oncogene homolog 2
Mass (kDA):
128.343 kDA
Human | |
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Location: | 1q25.2 |
Sequence: | 1; NC_000001.11 (179099330..179229693, complement) |
Widely expressed.
Cytoplasm, cytoskeleton.
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PMID: 2198571 by Kruh G.D., et al. The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases.
PMID: 18810762 by Bianchi C., et al. Eight full-length abelson related gene (Arg) isoforms are constitutively expressed in caki-1 cell line and cell distribution of two isoforms has been analyzed after transfection.
*More publications can be found for each product on its corresponding product page