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- Table of Contents
ABL2 Antibodies
AND ABL2 ELISA kits, ABL2 Proteins
Many biological assays use antibodies to detect ABL2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ABL2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ABL2 antibodies...
Designing a Western blot for ABL2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ABL2 Western Blot GuideDesigning an IHC experiment for ABL2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the ABL2 IHC GuideABL2 Infographic by Boster Bio
All ABL2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA
$540
Cat # EKC2643
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2643
1 kit, containing two 96-well plates and all necessary reagents
ABL2 Overview
Facts about Tyrosine-protein kinase ABL2.
Tyrosine-protein kinase ABL2 (ABL2)
Non-receptor tyrosine-protein kinase that plays an ABL1- overlapping function in key processes linked to cell growth and survival like cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics such as MYH10 (involved in motion ); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits).
Binds straight F-actin and regulates actin cytoskeletal structure through its F-actin- bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes like CRK, CRKL, DOK1 or ARHGAP35.
Gene Information
| Human | |
|---|---|
| Gene Name: | ABL2 |
| Uniprot: | P42684 |
| Entrez: | 27 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
Abelson murine leukemia viral (v-abl) oncogene homolog 2; Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; Abelson-relatedgene); arg tyrosine kinase; EC 2.7.10; EC 2.7.10.2; FLJ22224; FLJ31718; FLJ41441; tyrosine-protein kinase ABL2; Tyrosine-protein kinase ARG; v-abl Abelson murine leukemia viral oncogene homolog 2
Molecular Weight
Mass (kDA):
128.343 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q25.2 |
| Sequence: | 1; NC_000001.11 (179099330..179229693, complement) |
Tissue Specificity
Widely expressed.
Subcellular Localizations
Cytoplasm, cytoskeleton.
Diseases
- Malignant Neoplasms
- Leukemia
- Neoplasms
- Myeloid Leukemia
- Myeloid Leukemia, Chronic
- Carcinoma
- Chromosomal Translocation
- Tissue Adhesions
- Carcinogenesis
- Fracture Of First Cervical Vertebra
- Adenocarcinoma
- Hematologic Neoplasms
Interacting Proteins
- ABI1
- CRK
- EGFR
- ERBB2
- ERBB3
- ERBB4
- FLT3
- FYN
- GRB2
- KIT
Pathways
- Reverse Transcription
- Localization
- Pathogenesis
- Cell Migration
- Cell Proliferation
- Fertilization
- Immune Response
- Axon Guidance
- Dna Repair
- Cell Growth
- Protein Phosphorylation
- Cell Adhesion
- Proteolysis
PTMs
- Phosphorylation
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ABL2
bosterbio.com/bosterbio-gene-info-cards/ABL2
References
PMID: 2198571 by Kruh G.D., et al. The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases.
PMID: 18810762 by Bianchi C., et al. Eight full-length abelson related gene (Arg) isoforms are constitutively expressed in caki-1 cell line and cell distribution of two isoforms has been analyzed after transfection.