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- Table of Contents
65 Citations 18 Q&As
68 Citations 5 Q&As
122 Citations 2 Q&As
8 Citations 16 Q&As
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6 Citations 16 Q&As
8 Citations 16 Q&As
Facts about Actin, alpha skeletal muscle.
Human | |
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Gene Name: | ACTA1 |
Uniprot: | P68133 |
Entrez: | 58 |
Belongs to: |
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actin family |
ACTA; Actin; actin, alpha 1, skeletal muscle; alpha skeletal muscle actin; alpha skeletal muscle; alpha-actin-1; ASMA; CFTD; CFTDM; MPFD; NEM1; NEM2; NEM3
Mass (kDA):
42.051 kDA
Human | |
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Location: | 1q42.13 |
Sequence: | 1; NC_000001.11 (229431245..229434094, complement) |
Cytoplasm, cytoskeleton.
The ACTA1 protein is a conserved one with high levels of specificity. Boster Bio has validated this protein for use in a variety of samples that include animal and human. Additionally, it's assured to be of high-quality. In this article, we'll explore the most effective uses for this protein. We hope you be able to use it. We hope you enjoy reading this article!
The ACTA1 gene encodes a highly multifunctional, highly conserved protein within the muscle. Numerous muscle diseases are linked with mutations in ACTA1. However, only a few studies have examined the role of ACTA1 as a factor in these diseases. This is the first study to identify a mutation in Glu197, a highly conserved amino acid located in a high-exposure position in the protein. The mutation causes inter- and intramolecular electrostatic interactions to be affected.
The ACTA1 gene encodes a-actin the most well-known type of actin in adult muscles of the skeletal system. It is crucial for muscle contraction. 177 mutations have been discovered in ACTA1, resulting five congenital myopathies that overlap. There is no cure for these mutations. They vary in severity and frequency in different individuals.
Mutations in ACTA1 do not affect the ability of rods to be made. Instead, they affect the function of actin in the skeletal muscles. These mutations are likely dominant negative effects. The G-actin monomer mutation could hinder the formation of thin filaments, which can cause problems with the normal function of skeletal muscle a-actin.
There are many advantages of SOX11 in the diagnosis of liver cancer. Its high sensitivity makes it a useful marker for the differentiation of liver cancerous cells and hepatocytic. Its high specificity makes this a useful complement for other NE markers. SOX11 is not just highly sensitive, but it is also highly specific in detecting liver-related lesions. Furthermore, it's available in a wide variety of samples, making it an ideal method to assess the progress of liver cancer.
The ACTA1 gene encodes a highly conserved protein that is a crucial component of cytoskeletal and contractile structures. Actin levels vary based on the degree of differentiation and functional state of the cell. 90 percent sequence homology is shared by all Actin forms. There are three kinds of actin: beta-, gamma and beta-actin. The ACTA1 antibody is produced against a synthetic peptide that corresponds to the C-terminal 11 residues in actin. All antibodies from Boster Bio are validated using known positive and negative samples.
Immunohistochemistry (IHC) is an extremely popular method of detecting antigens in tissue samples is extremely popular. This method is based on the concept of binding antibodies to antigens within particular tissues. The enzymes responsible for producing color-producing reactions are used to identify the antigen-antibody combination. This technique is used in clinical and research laboratories. Tissue preparation is a crucial step in IHC because it directly influences the manifestation of antigens.
The ACTA1 protein is a highly conserved protein that is found in the majority of cells. It is a key component of contracts and cytoskeletal structures, and its quantity changes with the state of function and the type of differentiation. Actins are polysaccharides that have 90 90% sequence homology. The three forms are alpha-actin beta-actin and the gamma-actin. Each is distinguished by its C-11 residues. A synthetic peptide which corresponds to the C-terminal region of each isoform is used for the creation of the antibody. Boster validates all their antibodies using known positive or negative samples.
PMID: 6190133 by Hanauer A., et al. Isolation and characterization of cDNA clones for human skeletal muscle alpha actin.
PMID: 2907503 by Taylor A., et al. Nucleotide sequence and expression of the human skeletal alpha-actin gene: evolution of functional regulatory domains.
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