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Seems to contact the pointed end of their daughter actin filament (PubMed:9000076). Besides its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947).
|Sequence:||2; NC_000002.12 (113889934..113962596)|
Cytoplasm, cytoskeleton. Cell projection. Nucleus. In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes) (PubMed:19109554).