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- Table of Contents
Facts about Disintegrin and metalloproteinase domain-containing protein 15.
Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility towards or on fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation.
| Human | |
|---|---|
| Gene Name: | ADAM15 |
| Uniprot: | Q13444 |
| Entrez: | 8751 |

| Belongs to: |
|---|
| No superfamily |

ADAM 15; ADAM metallopeptidase domain 15; ADAM15; disintegrin-like, and cysteine-rich protein 15; EC 3.4.24; MDC15; MDC-15; Metargidin
Mass (kDA):
92.959 kDA

| Human | |
|---|---|
| Location: | 1q21.3 |
| Sequence: | 1; NC_000001.11 (155051316..155062775) |
Expressed in colon and small intestine. Expressed in airway smooth muscle and glomerular mesangial cells (at protein level). Ubiquitously expressed. Overexpressed in atherosclerotic lesions. Constitutively expressed in cultured endothelium and smooth muscle. Expressed in chondrocytes. Expressed in airway smooth muscle and glomerular mesangial cells.
Endomembrane system; Single-pass type I membrane protein. Cell junction, adherens junction. Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acrosome. The majority of the protein is localized in a perinuclear compartment which may correspond to the trans-Golgi network or the late endosome. The pro-protein is the major detectable form on the cell surface, whereas the majority of the protein in the cell is processed (By similarity).





PMID: 8617717 by Kraetzschmar J., et al. Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence.
PMID: 9039960 by Herren B., et al. Expression of a disintegrin-like protein in cultured human vascular cells and in vivo.