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- Table of Contents
ADAMTS5 Antibodies
AND ADAMTS5 ELISA kits, ADAMTS5 Proteins
Many biological assays use antibodies to detect ADAMTS5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ADAMTS5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ADAMTS5 antibodies...
Designing a Western blot for ADAMTS5? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ADAMTS5 Western Blot GuideADAMTS5 Infographic by Boster Bio
All ADAMTS5 Products
Product
Figures
Specificity
Applications
Price
Anti-ADAMTS5 Antibody Picoband®
22 Citations
Human, Mouse, Rat
ELISA, IHC, WB
$370
Cat # A02802-1
100 μg/vial
Cat # A02802-1
100 μg/vial
ADAMTS5 Overview
Facts about A disintegrin and metalloproteinase with thrombospondin motifs 5.
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5)
Metalloproteinase that plays an significant role in connective tissue organization, development, inflammation, arthritis, and cell migration. ADAMTS5 is an extracellular matrix (ECM) degrading enzyme that reveal proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) such as aggrecan, versican, brevican and neurocan (PubMed:16133547, PubMed:18992360).
Cleavage within the hyalectans happens at Glu-Xaa recognition motifs. Plays a role in embryonic development, such as limb and cardiac morphogenesis, and skeletal muscle development through its versican remodeling properties.
Gene Information
| Human | |
|---|---|
| Gene Name: | ADAMTS5 |
| Uniprot: | Q9UNA0 |
| Entrez: | 11096 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
A disintegrin and metalloproteinase with thrombospondin motifs 11; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 5 (aggrecanase-2); ADAM metallopeptidase with thrombospondin type 1 motif, 5; ADAM-TS 11; ADAM-TS 5; ADAMTS11; ADAMTS-11; ADAMTS5; ADAM-TS5; ADAMTS-5; ADMP2; ADMP-2; ADMP-2A disintegrin and metalloproteinase with thrombospondin motifs 5; Aggrecanase 2; aggrecanase-2; disintegrin-like and metalloprotease with thrombospondin type 1 motif, 510ADAMTS11FLJ36738; EC 3.4.24; EC 3.4.24.-; EC 3.4.24.14; EC 3.4.24.82
Molecular Weight
Mass (kDA):
101.718 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 21q21.3 |
| Sequence: | 21; NC_000021.9 (26917922..26967758, complement) |
Tissue Specificity
Expressed at low level in placenta primarily but also detected in heart and brain, cervix, uterus, bladder, esophagus, rib cartilage, chondroblastoma, fibrous tissue and a joint capsule from an arthritic patient.
Subcellular Localizations
Secreted, extracellular space, extracellular matrix.
Diseases
- Degenerative Polyarthritis
- Arthritis
- Abnormal Degeneration
- Osteoarthritis, Knee
- Rheumatoid Arthritis
- Intervertebral Disc Degeneration
- Inflammation
- Arthropathy
- Tumor Angiogenesis
- Malignant Neoplasms
- Neoplasms
- Chondrosarcoma
Pathways
- Pathogenesis
- Proteolysis
- Cell Proliferation
- Localization
- Angiogenesis
- Aging
- Secretion
- Ossification
- Chondrocyte Hypertrophy
- Regeneration
- Dedifferentiation
- Cell Death
- Cell Adhesion
PTMs
- Cleavage
- Phosphorylation
- Methylation
- Glycosylation
- Carboxylation
Research Areas
- GPCR
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ADAMTS5
bosterbio.com/bosterbio-gene-info-cards/ADAMTS5
References
PMID: 10438522 by Abbaszade I., et al. Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family.
PMID: 10464288 by Hurskainen T.L., et al. ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases.
9 Publications of Boster ADAMTS5 Antibodies & ELISA Kits
- PubMed ID: 10.3389/fphar.2021.761922, Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 ...
- PubMed ID: 10.3389/fphar.2021.730312, Selective STAT3 Inhibitor Alantolactone Ameliorates Osteoarthritis via Regulatin...
- PubMed ID: 10.18632/aging.102586, Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic a...
- PubMed ID: 10.1155/2021/4139048, MCC950, the NLRP3 Inhibitor, Protects against Cartilage Degradation in a Mouse M...
- PubMed ID: 10.1007/s10753-019-01142-7, p-Coumaric Acid Attenuates IL-1β-Induced Inflammatory Responses and Cellular Se...
- PubMed ID: 34090897, Huang X,Pei W,Ni B,Zhang R,You H.Chondroprotective and antiarthritic effects of ...
- PubMed ID: 32628132, Chu X,Yu T,Huang X,Xi Y,Ni B,Zhang R,You H.Tomatidine suppresses inflammation in...
- PubMed ID: ,
- PubMed ID: 33130473, Sun K,Luo J,Jing X,Xiang W,Guo J,Yao X,Liang S,Guo F,Xu T.Hyperoside ameliorates...
*More publications can be found for each product on its corresponding product page