ADP-ribose glycohydrolase ARH3 (Adprhl2)

Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be needed for maintenance of the normal function of neuronal cells.

Generates ADP-ribose from poly-(ADP-ribose), but doesn't hydrolyze ADP- ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the sole PAR hydrolyzing enzyme in mitochondria (By similarity).