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- Table of Contents

Facts about Cytosolic carboxypeptidase 6.
Also removes polyglutamates from the carboxy-terminus of target proteins like MYLK (PubMed:21074048). Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS (PubMed:26829768).
| Mouse | |
|---|---|
| Gene Name: | Agbl4 |
| Uniprot: | Q09LZ8 |
| Entrez: | 78933 |

| Belongs to: |
|---|
| peptidase M14 family |

ATP/GTP binding protein-like 4; ATP/GTP-binding protein-like 4; CCP6; cytosolic carboxypeptidase 6; EC 3.4.17.-; FLJ14442
Mass (kDA):
62.21 kDA

| Mouse | |
|---|---|
| Location: | 4|4 C7-D1 |
| Sequence: | 4; |
Widely expressed. Expressed abundantly in testis, pituitary and brain and to a lower extent in eye, stomach, adrenal and kidney. In brain, expressed at low level in cerebellum as compared to cortex.

PMID: 17244818 by Kalinina E., et al. A novel subfamily of mouse cytosolic carboxypeptidases.
PMID: 21074048 by Rogowski K., et al. A family of protein-deglutamylating enzymes associated with neurodegeneration.