AIMP2 Antibodies

Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)

Required for assembly and stability of the aminoacyl- tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, resulting in MYC down-regulation which is required for aveolar type II cell differentiation.

Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.

Gene Information

Human
Gene Name:	AIMP2
Uniprot:	Q13155
Entrez:	7965

Family

Belongs to:
No superfamily

Alternative Names

aminoacyl tRNA synthase complex-interacting multifunctional protein 2; aminoacyl tRNA synthetase complex-interacting multifunctional protein 2; ARS-interacting multi-functional protein 2; JTV1JTV-1; Multisynthase complex auxiliary component p38; multisynthetase complex auxiliary component p38; P38; PRO0992; Protein JTV-1

Molecular Weight

Mass (kDA):
35.349 kDA

Genomic Context

Human
Location:	7p22.1
Sequence:	7; NC_000007.14 (6009245..6023834)

Subcellular Localizations

Cytoplasm, cytosol. Nucleus. Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.

Diseases

• Malignant Neoplasms
• Neoplasms
• Lung Neoplasms
• Malignant Neoplasm Of Lung
• Cell Transformation, Neoplastic
• Parkinson Disease
• Autoimmunity
• Stomach Neoplasms
• Papilloma
• Neurodegenerative Disorders
• Colonic Neoplasms
• Carcinogenesis

• Neoplasms, Glandular And Epithelial
• Nervousness
• Malignant Neoplasm Of Ovary
• Epithelial Ovarian Cancer
• Colorectal Cancer
• Ovarian Neoplasm
• Cell Invasion

Interacting Proteins

• AIMP1
• BCAS2
• BYSL
• C19orf57
• CEP170P1

• DARS
• FHL3
• FUBP1
• GYS1
• KARS

• LMO2
• LNX1
• MIS18A
• NDEL1
• PCMT1

• PLEKHF2
• PRKAA2
• SPATA18
• TERF2IP
• TFIP11

• TP53
• ZGPAT

Pathways

• Cell Death
• Translation
• Cell Proliferation
• Response To Oxidative Stress
• Lung Cell Differentiation
• Cellular Homeostasis
• Regulation Of Cell Proliferation
• Cell Differentiation
• Cell Growth

• Cellular Response To Oxidative Stress
• Pathogenesis
• Autophagy

PTMs

• Phosphorylation

• Ubiquitination

• Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AIMP2

Boster Bio: Best Uses Of The AIMP2 Marker

Boster Bio is a brand you may have heard of if you are looking for an antibody that detects AIMP2 proteins. You might be curious about how Boster Bio validates their products on WB and IHC, ICC. Immunofluorescence and ICC-FRET. We will discuss the history and future of Boster Bio. Also, how you can make use of this antibody in your own research.

Boster Bio: Anti AIMP2/p38 antibody

Boster Bio: Anti AIMP2/P38 antibody against the AIMP2 marker recognizes AIMP2. This antibody targets the aminoacyltRNAsynthesise complex interacting multifunctionalprotein 2 (also known as P38. JTV1 or HLD17). The anti-AIMP2 antibody has been tested in a WB assay. It was able to react with Rat, Mouse, and Human.

This monoclonal antibodies recognizes AIMP2, a crucial protein in the differentiation process of lung cells. It can also act as a mediator of TGF beta signaling and has functional importance in the regulation or MYC of lung differentiation. It is particularly useful in immunohistochemistry as a biomarker in determining AIMP2 expression levels in tissues.

Steven Boster's history

Steve Boster was born in 1993. He is known as "he who converts science into the lavatory". He has been a prolific inventor, developing hundreds of primary antibodies and various products for the field of immunohistochemistry. By the late 1990s, Steven Boster had become one of China's largest catalog antibody companies. PicoKine(tm), his proprietary ELISA platform, was also developed by Boster to create high-sensitivity ELISA kit.

Steve Boster was born Joliet, IL. He was a manager in retail sales for many years and was a member of Concordia Hall in Staunton. He is survived by his two daughters, Natosha Poeck and Crystal Boster. He also leaves behind 6 grandchildren, 4 brothers (Sandra Blanton and Jack Boster) and several nieces and nephews. Below is a brief description of Steve Boster’s life and legacy.

Boster validates every antibody on WB. IHC. ICC. Immunofluorescence.

The company has been in the business of developing and manufacturing quality antibodies for the life sciences since 1993. The company was called "he Who Converts Science in the Lavatory" because it developed products from WB and IHC as well hundreds of primary antibodies. It was China's largest catalogue antibody manufacturer by the late 1990s. With a proprietary ELISA platform called PicoKine(tm), Boster Bio was able to develop high-sensitivity ELISA kits.

Boster has over 16,000 antibodies that have been tested on IHC, ICC, WB and Immunofluorescence. These antibodies have high affinity and are trusted by the research community. They are validated for use in Western Blotting, Immunohistochemistry, ELISA, FC, and ICC. Boster offers both monoclonal as well as polyclonal antibody, as well a secondary antibody at no cost.

Boster Bio validates every antibody on WBC or IHC using multiple controls to ensure precision. The ideal situation is to detect only one band for a given antibody. This indicates that it is specific for the target proteins.

Monoclonal antibodies clones are most commonly used and preferred in immunoassays. This is because they are highly specific to the target protein. Monoclonal antibodies are able to eliminate any potential problems with consistency. You'll also save money as they aren't expensive.

Among the many diseases that can be diagnosed using immunofluorescence is a rare disease known as pemphigus vulgaris. This autoimmune disorder is characterized by suprabasal blemishes and granular IgA deposited. Dermatitis HERpetiformis, another condition where immunofluorescence can confirm the diagnosis, is also possible. IgA antibodies can also be detected with a specialized immunofluorescent dye.

Secondary antibodies are an antibody that binds with an antigen. It is created by immunizing a host with an antigen of another species. A secondary antibody is a rabbit monoclonal antibody, which has been raised in a different species. The characteristics of immunized antibodies determine the quality of secondary antibody.

Applications of this antibody

The AIMP2-DX2 cancer-related protein provides information that can be used to determine the likelihood or development of cancer. The marker could be expressed in the form a biomolecule or protein. It can be expressed within cancer cells, which can help doctors to diagnose the condition and improve treatment options. AIMP2-DX2 is also expressed in many types cancers, including colon, liver, lung, and colon.

The AIMP2-DX2 genes is expressed in the nuclei and epithelial cells of the alveolar epithelial cells. This genetic mutation can cause neonatal death in mice. Transient expression of AIMP2-DX2 in these cells causes the cells to undergo overproliferation. The gene is expressed by transforming growth factors-b, which induces AIMP2 and promotes AIMP2 nucleus translocation.

RNA-smFISH enables the detection of the AIMP2-DX2 gene in cell samples. This method is highly sensitive, accurate, and can subclassify cell types based on AIMP2-DX2 expression. This new method can also be used for identifying the levels of mRNAs expressed by cancer-cell cells. It also allows multiplex single-molecule fluorescence imaging (ISH), which allows comparison of the AIMP2-DX2 transcript.

AIMP2 has been demonstrated to be a powerful tumor suppressor. Its widespread activity against various types and types of cancers reflects its high coverage. AIMP2-DX2 mutations were also found in tumor-producing haploid mouse models. These mice had a higher susceptibility for carcinogenic treatment. The findings of the current study suggest that AIMP2-DX2 gene may be an important biomarker for lung cancer.

AIMP2-DX2 is a biomarker that has been receiving increasing attention. In vivo research showed that AIMP2-DX2 decreased the growth of cancer cells and tumors. Researchers may be able to identify patients with cancer who might benefit from AIMP2-DX2-targeted therapies by quantifying AIMP2-DX2's expression. Although there is still much research needed to determine the expression level for AIMP2-DX2 in different types and cancers, this tool is already promising.

The AIMP2 gene is a gene and consists of four exons. It produces polypeptides in the indicated sizes. The corresponding primers are used to schematically represent the sequence for the human AIMP2-DX2 protein gene. The hybridization reaction probes are specifically designed to contain the junction sequence between exons 1, 3 and 4. They have been proven to be especially effective. This technique uses primers to amplify the AIMP2-DX2 genome.