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- Table of Contents
AIMP2 Antibodies
AND AIMP2 ELISA kits, AIMP2 Proteins
Many biological assays use antibodies to detect AIMP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AIMP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AIMP2 antibodies...
Designing an IHC experiment for AIMP2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the AIMP2 IHC GuideAIMP2 Infographic by Boster Bio
All AIMP2 Products
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AIMP2 Overview
Facts about Aminoacyl tRNA synthase complex-interacting multifunctional protein 2.
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)
Required for assembly and stability of the aminoacyl- tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, resulting in MYC down-regulation which is required for aveolar type II cell differentiation.
Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
Gene Information
| Human | |
|---|---|
| Gene Name: | AIMP2 |
| Uniprot: | Q13155 |
| Entrez: | 7965 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
aminoacyl tRNA synthase complex-interacting multifunctional protein 2; aminoacyl tRNA synthetase complex-interacting multifunctional protein 2; ARS-interacting multi-functional protein 2; JTV1JTV-1; Multisynthase complex auxiliary component p38; multisynthetase complex auxiliary component p38; P38; PRO0992; Protein JTV-1
Molecular Weight
Mass (kDA):
35.349 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7p22.1 |
| Sequence: | 7; NC_000007.14 (6009245..6023834) |
Subcellular Localizations
Cytoplasm, cytosol. Nucleus. Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Lung Neoplasms
- Malignant Neoplasm Of Lung
- Cell Transformation, Neoplastic
- Parkinson Disease
- Autoimmunity
- Stomach Neoplasms
- Papilloma
- Neurodegenerative Disorders
- Colonic Neoplasms
- Carcinogenesis
Interacting Proteins
- AIMP1
- BCAS2
- BYSL
- C19orf57
- CEP170P1
- DARS
- FHL3
- FUBP1
- GYS1
- KARS
Pathways
- Cell Death
- Translation
- Cell Proliferation
- Response To Oxidative Stress
- Lung Cell Differentiation
- Cellular Homeostasis
- Regulation Of Cell Proliferation
- Cell Differentiation
- Cell Growth
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AIMP2
bosterbio.com/bosterbio-gene-info-cards/AIMP2
References
PMID: 8666379 by Nicolaides N.C., et al. Analysis of the 5' region of PMS2 reveals heterogeneous transcripts and a novel overlapping gene.
PMID: 24312579 by Kim K., et al. Reinvestigation of aminoacyl-tRNA synthetase core complex by affinity purification-mass spectrometry reveals TARSL2 as a potential member of the complex.
6 Publications of Boster AIMP2 Antibodies & ELISA Kits
- PubMed ID: 33856409, Wu T,Liu Q,Li Y,Li H,Chen L,Yang X,Tang Q,Pu S,Kuang J,Li R,Huang Y,Zhang J,Zhan...
- PubMed ID: 32794226, Ma G,Kimatu BM,Yang W,Pei F,Zhao L,Du H,Su A,Hu Q,Xiao H.Preparation of newly id...
- PubMed ID: 31566725, Ji F,Wang Y,Yuan J,Wu Q,Wang J,Liu D.The potential role of stromal cell-derived ...
- PubMed ID: 24789581, Zheng Q, Liu Y, Liu W, Ma F, Zhou Y, Chen M, Chang J, Wang Y, Yang G, He G. Mol ...
- PubMed ID: 24700345, Zhao B, Li X. Oncol Rep. 2014 Jun;31(6):2769-75. Doi: 10.3892/Or.2014.3126. Epub...
- PubMed ID: 24275644, Sun Y, Yang J, Wang Lz, Sun Lr, Dong Q. Hum Exp Toxicol. 2014 Aug;33(8):855-62. ...
*More publications can be found for each product on its corresponding product page