- Table of Content
Adenylate kinase activity is critical for regulation of the phosphate utilization as well as the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
|adenylate kinase family|
|Sequence:||1; NC_000001.11 (33007940..33036911, complement)|
Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood, while AK1 is mostly absent. In spleen and lymph nodes, mononuclear cells lack AK1, whereas AK2 is readily detectable. These results indicate that leukocytes may be susceptible to defects caused by the lack of AK2, as they do not express AK1 in sufficient amounts to compensate for the AK2 functional deficits (at protein level).
Mitochondrion intermembrane space.