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A-kinase anchor protein 8 Antibodies
AND AKAP8 ELISA kits, A-kinase anchor protein 8 Proteins
Many biological assays use antibodies to detect A-kinase anchor protein 8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with A-kinase anchor protein 8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop A-kinase anchor protein 8 antibodies...
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AKAP8 Infographic by Boster Bio
All AKAP8 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1634
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1634
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
IHC, ICC, WB
$405
Cat # A05133-1
100ul
Cat # A05133-1
100ul
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A05133-2
100 μg/vial
Cat # A05133-2
100 μg/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M05133
100 μl/vial
Cat # M05133
100 μl/vial
AKAP8 Overview
Facts about A-kinase anchor protein 8.
A-kinase anchor protein 8 (AKAP8)
Anchoring protein which mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is needed for maintenance of chromosomes in a condensed form throughout mitosis.
Recruits condensin complex subunit NCAPD2 into chromosomes necessary for chromatin condensation; the function seems to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to ease cell cycle progression (PubMed:14641107).
Gene Information
| Human | |
|---|---|
| Gene Name: | AKAP8 |
| Uniprot: | O43823 |
| Entrez: | 10270 |
Family
| Belongs to: |
|---|
| AKAP95 family |
Alternative Names
A kinase (PRKA) anchor protein 8; AKAP-8; AKAP-95 AKAP 95; A-kinase anchor protein 8; A-kinase anchor protein 95 kDa; A-kinase anchor protein, 95kDa; DKFZp586B1222
Molecular Weight
Mass (kDA):
76.108 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.12 |
| Sequence: | 19; NC_000019.10 (15353385..15379787, complement) |
Tissue Specificity
Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Expressed in mature dendritic cells.
Subcellular Localizations
Nucleus. Nucleus matrix. Nucleus, nucleolus. Cytoplasm. Associated with the nuclear matrix in interphase and redistributes mostly to chromatin at mitosis. However, mitotic chromatin localization has been questioned. Upon nuclear reassembly at the end of mitosis, is sequestered into the daughter nuclei where it re-acquires an interphase distribution. Localized to the nucleolus in interphase. Colocalizes with GJA1 at the nuclear membrane specifically during cell cycle G1/S phase.
Diseases
- Malignant Neoplasms
- Glioma
- Inflammation
- Cleft Palate
- Aortic Aneurysm, Abdominal
Interacting Proteins
- ASH2L
- CASP3
- DPY30
- HDAC3
- MCM2
- PRKAR2A
- RPS6KA1
- WDR5
Pathways
- Localization
- Cell Cycle
- Transport
- Cell Activation
- Insulin Secretion
- Camp-mediated Signaling
- Mitosis
- Fertilization
- T Cell Activation
- Proteolysis
- Histone Modification
PTMs
- Phosphorylation
- Deacetylation
Research Areas
- Cancer
- Cell Cycle and Replication
- Mitotic Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AKAP8
bosterbio.com/bosterbio-gene-info-cards/AKAP8
References
PMID: 9473338 by Eide T., et al. Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95.
PMID: 10601332 by Collas P., et al. The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis.