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Recruits condensin complex subunit NCAPD2 into chromosomes necessary for chromatin condensation; the function seems to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to ease cell cycle progression (PubMed:14641107).
|Sequence:||19; NC_000019.10 (15353385..15379787, complement)|
Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Expressed in mature dendritic cells.
Nucleus. Nucleus matrix. Nucleus, nucleolus. Cytoplasm. Associated with the nuclear matrix in interphase and redistributes mostly to chromatin at mitosis. However, mitotic chromatin localization has been questioned. Upon nuclear reassembly at the end of mitosis, is sequestered into the daughter nuclei where it re-acquires an interphase distribution. Localized to the nucleolus in interphase. Colocalizes with GJA1 at the nuclear membrane specifically during cell cycle G1/S phase.