A-kinase anchor protein 8 (AKAP8)

Anchoring protein which mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is needed for maintenance of chromosomes in a condensed form throughout mitosis.

Recruits condensin complex subunit NCAPD2 into chromosomes necessary for chromatin condensation; the function seems to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to ease cell cycle progression (PubMed:14641107).