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THO complex subunit 4 Antibodies
AND ALYREF ELISA kits, THO complex subunit 4 Proteins
Many biological assays use antibodies to detect THO complex subunit 4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with THO complex subunit 4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop THO complex subunit 4 antibodies...
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ALYREF Infographic by Boster Bio
All ALYREF Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M03580
100 μl/vial
Cat # M03580
100 μl/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A03580-3
100 μg/vial
Cat # A03580-3
100 μg/vial
ALYREF Overview
Facts about THO complex subunit 4.
THO complex subunit 4 (ALYREF)
Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA.
TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and can be recruited in a splicing- and cap-dependent way to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm. TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1.
Gene Information
| Human | |
|---|---|
| Gene Name: | ALYREF |
| Uniprot: | Q86V81 |
| Entrez: | 10189 |
Family
| Belongs to: |
|---|
| ALYREF family |
Alternative Names
Ally of AML-1 and LEF-1; ALY/REF; ALYBEFbZIP enhancing factor; bZIP-enhancing factor BEF; REF; THO complex 4; THO complex subunit 4; tho4; Transcriptional coactivator Aly/REF
Molecular Weight
Mass (kDA):
26.888 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q25.3 |
| Sequence: | 17; NC_000017.11 (81887835..81891587, complement) |
Tissue Specificity
Expressed in a wide variety of cancer types.
Subcellular Localizations
Nucleus. Nucleus speckle. Cytoplasm. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and DDX39B in the nucleus and nuclear speckles. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA (PubMed:19324961). Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur (PubMed:23826332).
Diseases
- Malignant Neoplasms
- Neoplasms
- Leukemia, T-cell
- Mammary Neoplasms
- Htlv-i Infections
- Malignant Neoplasm Of Skin
- Leukemia
- Oncogene Activation Process
- Sarcoma
- Carcinoma
- Leukemia, Myelocytic, Acute
- Acute Erythroblastic Leukemia
Interacting Proteins
- AKT1
- CDK1
- CHTOP
- DDX39B
- NXF1
Pathways
- Nuclear Export
- Localization
- Translation
- Transport
- Cell Proliferation
- Mrna Transport
- Methylation
- Viral Replication
- Mitosis
- Dna Integration
- Dna Repair
- Cytokinesis
- Mrna Transcription
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ALYREF
bosterbio.com/bosterbio-gene-info-cards/ALYREF
References
PMID: 9952027 by Wichmann I., et al. Autoantibodies to transcriptional regulation proteins DEK and ALY in a patient with systemic lupus erythematosus.
PMID: 12176931 by Rappsilber J., et al. Large-scale proteomic analysis of the human spliceosome.