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Involved in cell differentiation and cell adhesion and migration, plays an essential role in retinal tissue morphogenesis, neural tube combination, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras into the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity).
|Sequence:||19; NC_000019.10 (46860997..47005077)|
Detected in neutrophils (at protein level).
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm. Nucleus. Cell membrane. In response to integrins and SDC4 and upon phosphorylation by PKC, relocalizes from the cytoplasm to regions of plasma membrane ruffling where it colocalizes with polymerized actin.