Rho GTPase-activating protein 35 (ARHGAP35)

Binds several acidic phospholipids which inhibits the Rho GAP activity to foster the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492).

Involved in cell differentiation and cell adhesion and migration, plays an essential role in retinal tissue morphogenesis, neural tube combination, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras into the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity).