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ARHGAP35 Antibodies
AND ARHGAP35 ELISA kits, ARHGAP35 Proteins
Many biological assays use antibodies to detect ARHGAP35, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ARHGAP35 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ARHGAP35 antibodies...
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ARHGAP35 Infographic by Boster Bio
All ARHGAP35 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IHC-P, WB, IF (paraffin)
$335
Cat # P30433
100ul
Cat # P30433
100ul
Human, Mouse, Rat
ELISA, WB
$380
Cat # A03592Y1087-1
100ul
Cat # A03592Y1087-1
100ul
ARHGAP35 Overview
Facts about Rho GTPase-activating protein 35.
Rho GTPase-activating protein 35 (ARHGAP35)
Binds several acidic phospholipids which inhibits the Rho GAP activity to foster the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492).
Involved in cell differentiation and cell adhesion and migration, plays an essential role in retinal tissue morphogenesis, neural tube combination, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras into the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | ARHGAP35 |
| Uniprot: | Q9NRY4 |
| Entrez: | 2909 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
glucocorticoid receptor DNA binding factor 1; glucocorticoid receptor DNA-binding factor 1; glucocorticoid receptor repression factor 1; GRF1; GRF-1; GRLF1; KIAA1722; MGC10745; P190A; P190-A; p190ARhoGAP; p190RhoGAP; rho GAP p190A; Rho GTPase activating protein 35; rho GTPase-activating protein 35
Molecular Weight
Mass (kDA):
170.514 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.32 |
| Sequence: | 19; NC_000019.10 (46860997..47005077) |
Tissue Specificity
Detected in neutrophils (at protein level).
Subcellular Localizations
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm. Nucleus. Cell membrane. In response to integrins and SDC4 and upon phosphorylation by PKC, relocalizes from the cytoplasm to regions of plasma membrane ruffling where it colocalizes with polymerized actin.
Diseases
- Tissue Adhesions
- Malignant Neoplasms
- Cell Invasion
- Neoplasms
- Neoplasm Invasiveness
- Carcinoma
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Melanoma
- Tumor Angiogenesis
- Neoplasm Metastasis
- Glioma
- Pathologic Neovascularization
Pathways
- Cell Migration
- Cell Adhesion
- Cytokinesis
- Cell Proliferation
- Mitosis
- Angiogenesis
- Cell Cycle
- Mammary Gland Development
- Cell Division
- Cell Motility
- Cell-cell Adhesion
- Gland Development
- Cellular Process
PTMs
- Phosphorylation
- Cleavage
- Ubiquitination
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ARHGAP35
bosterbio.com/bosterbio-gene-info-cards/ARHGAP35
References
PMID: 11054565 by Tikoo A., et al. p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas.
PMID: 1894621 by LeClerc S., et al. Molecular cloning and characterization of a factor that binds the human glucocorticoid receptor gene and represses its expression.