ADP-ribosylation factor-like protein 6 (Arl6)

Involved in membrane protein trafficking at the bottom of the ciliary organelle (By similarity). Mediates recruiting onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of certain membrane proteins to the primary cilia (By similarity).

Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (PubMed:24939912). Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway law (By similarity).