ARPC4 Antibodies

AND ARPC4 ELISA kits, ARPC4 Proteins

Many biological assays use antibodies to detect ARPC4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ARPC4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ARPC4 antibodies...

We validate the specificity of these antibodies to ARPC4 by testing them on tissues known to express ARPC4 positively and negatively. Browse below to find the ARPC4 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ARPC4 Infographic by Boster Bio

All ARPC4 Products

Product

Figures

Specificity

Applications

Price

ARPC4 (NM_005718) Human Over-expression Lysate

Human

$628
Cat # LS010093
100 µg

ARPC4 Overview

Facts about Actin-related protein 2/3 complex subunit 4.

ARPC4 3D structure. Source: alphafold

Actin-related protein 2/3 complex subunit 4 (ARPC4)

Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079).

In addition to its function in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by encouraging nuclear actin polymerization, resulting in drive motility of double-strand breaks (DSBs) (PubMed:29925947).

Gene Information

Human
Gene Name:	ARPC4
Uniprot:	P59998
Entrez:	10093

Family

Belongs to:

ARPC4 family

Alternative Names

actin related protein 2/3 complex, subunit 4, 20kDa; actin-related protein 2/3 complex subunit 4; arp2/3 protein complex subunit p20; MGC13544; p20-Arc; subunit 4 (20 kD)

Molecular Weight

Mass (kDA):
19.667 kDA

Genomic Context


Human

Location:	3p25.3
Sequence:	3; NC_000003.12 (9792495..9807724)

Subcellular Localizations

Cytoplasm, cytoskeleton. Cell projection. Nucleus.

Diseases

Wiskott-aldrich Syndrome
Hyperalgesia
Malignant Neoplasms
Diabetes Mellitus, Experimental
Pain
Hyperalgesias, Mechanical
Painful Diabetic Neuropathies
Tissue Adhesions

Malignant Neoplasm Of Pancreas
Diabetic Neuropathies
Diabetes Mellitus

Interacting Proteins

ARPC3
ARPC5L
PNMA5

Pathways

Cell Growth
Actin Nucleation
Endocytosis
Transport
Intracellular Transport
Cell Migration
Locomotion

Localization
Cell-cell Adhesion

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ARPC4

References

PMID: 9359840 by Machesky L.M., et al. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins.

PMID: 9230079 by Welch M.D., et al. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly.