Acid-sensing ion channel 1 (ASIC1)

Isoform 2 and isoform 3 be the proton-gated sodium channels; they are activated by a fall of the extracellular pH and become rapidly desensitized. The station generates a biphasic current with a fast inactivating and a slow sustained phase.

Has high selectivity for sodium ions and can also transfer lithium ions with higher efficiency. Isoform 2 can also transport potassium, but with lower efficiency.