Isoaspartyl peptidase/L-asparaginase (Asrgl1)

Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the creation of L-aspartate, which can act as an excitatory neurotransmitter in certain brain regions.

Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L- Asp-L-Lys.