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Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL contributes to the downstream activation of the AKT kinase.
|protein kinase superfamily|
|Sequence:||19; NC_000019.10 (41219223..41261767)|
Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.
Cell membrane; Single-pass type I membrane protein.