BRCA2 Antibodies

Breast cancer type 2 susceptibility protein (BRCA2)

Involved in double-strand fracture repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA).

Acts by targeting RAD51 to ssDNA over double-stranded DNA, allowing RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Section of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR.

Gene Information

Human
Gene Name:	BRCA2
Uniprot:	P51587
Entrez:	675

Family

Belongs to:
No superfamily

Alternative Names

BRCA1/BRCA2-containing complex, subunit 2; BRCA2; BRCC2; breast and ovarian cancer susceptibility gene, early onset; breast cancer 2 tumor suppressor; breast cancer 2, early onset; breast cancer susceptibility protein BRCA2; breast cancer type 2 susceptibility protein; BROVCA2; FACD; FAD; FAD1; FANCB; FANCD; FANCD1Fanconi anemia, complementation group D1; Fanconi anemia group D1 protein; GLM3; PNCA2

Molecular Weight

Mass (kDA):
384.202 kDA

Genomic Context

Human
Location:	13q13.1
Sequence:	13; NC_000013.11 (32315508..32400268)

Tissue Specificity

Highest levels of expression in breast and thymus, with slightly lower levels in lung, ovary and spleen.

Subcellular Localizations

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Diseases

• Malignant Neoplasms
• Mammary Neoplasms
• Malignant Neoplasm Of Breast
• Neoplasms
• Malignant Neoplasm Of Ovary
• Ovarian Neoplasm
• Brca2 Gene Mutation
• Carcinoma
• Brca1 Gene Mutation
• Hereditary Breast Carcinoma
• Cell Transformation, Neoplastic
• Anemia
• Breast Neoplasms, Male

• Malignant Neoplasm Of Prostate
• Epithelial Ovarian Cancer
• Genomic Instability
• Malignant Neoplasm Of Pancreas
• Pancreatic Neoplasm
• Adenocarcinoma
• Prostatic Neoplasms

Interacting Proteins

• DMC1
• FANCD2
• HMG20B
• PALB2
• PDS5B

• POLH
• RAD51
• SEM1
• TP53

Pathways

• Dna Repair
• Cell Cycle
• Pathogenesis
• Localization
• Hypersensitivity
• Methylation
• Cell Proliferation
• Double-strand Break Repair
• Dna Replication
• Mismatch Repair
• Cell Growth
• Cell Death
• Meiosis

• Menopause
• Translation
• S Phase
• Recombinational Repair
• Mitosis
• Cell Division
• Rna Interference

PTMs

• Methylation
• Phosphorylation
• Ubiquitination
• Cleavage
• Acetylation

• Demethylation
• Glycosylation
• Dephosphorylation
• Reduction
• Deacetylation

• Oxidation

Research Areas

• Breast Cancer
• Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BRCA2

Boster Bio - Best Uses Of The BRCA2 Marker

You may be asking yourself, "Who is Steven Boster?" This article will give you a comprehensive look at Steven Boster’s biography, career and research on BRCA2. You'll also find out about the ISH primes he created and their effectiveness. We hope you enjoy reading! We hope you enjoy the read and feel encouraged to use BRCA2 markers in your own research.

His research on BRCA2

His research on BRCA2 gene variants has been published in Science in 2007. His team discovered over the years that these mutations were associated a higher risk for different types of cancer. One study found that mutations in the BRCA2 gene group were associated with 16.7% and 23.5 percent respectively of breast cancer cases. In another study, mutation carriers and an elevated risk of cancer were not found to be associated in a second study.

Before the genome mapping was created, the team had focused on a single abnormal section. They then looked for similar flaws in other samples. Ultimately, they discovered the BRCA2 gene. His team published their findings in Nature journal in December 1995. These scientists' work opened the door to new treatments for BRCA-related cancers. Stratton's discoveries are being studied in laboratories around the world.

The BRCA1 gene is expressed in cells throughout the body. BRCA2 & BRCA1 protein interact with many proteins involved in biological process. The BRCA genes are crucial in the development of breast cancer. Among the many roles they play, they regulate DNA damage control and cell cycle. These genes can cause cancer by triggering cellular responses that may lead to the formation of other types of cancer. Consequently, it is essential to understand the role of these genes in various cancer types.

The discovery of the BRCA gene led to the development of improved treatments and cancer risk prediction. Stratton's research on BRCA2 gene has paved the way for future studies on other genes. The BRCA gene discovery opened the door to new research on how certain DNA variations can affect the development of breast carcinoma. Stratton scientists are currently developing a method that can predict breast cancer risk using as many as 300 genetic indicators.

Anti-BRCA2 antibodies

The BRCA2 gene, which is a hereditary trait, can be attributed to hormone treatment. A significant number of breast cancer cases can also be attributed hormonal treatment. The BRCA2 genetic marker is therefore an important marker in cancer research. Boster Bio provides antibodies that are specific for the BRCA2 genes. Anti-cerbB2 monoclonal antibody is the antibody that detects the BRCA2 gene.

BRCA1 (or BRCA2) genes are expressed in the breasts and other tissues. They play an important role in DNA repair. A disruption of this gene can lead to cancer. BRCA1 & BRCA2 interact with E6 & E7 proteins which alter their activity. They also interact to the genes RB, p53, and act co-activators of p53 mediated transcript. HPV proteins can also affect the function of the BRCA1 RB genes.