Cell division cycle protein 27 homolog (CDC27)

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of'Lys-48'- and'Lys-63'-linked polyubiquitin chains.