This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
CDK12 Antibodies
AND CDK12 ELISA kits, CDK12 Proteins
Many biological assays use antibodies to detect CDK12, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CDK12 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CDK12 antibodies...
Designing a Western blot for CDK12? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CDK12 Western Blot GuideDesigning an IHC experiment for CDK12? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the CDK12 IHC GuideCDK12 Infographic by Boster Bio
All CDK12 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # A03495-1
100 μg/vial
Cat # A03495-1
100 μg/vial
CDK12 Overview
Facts about Cyclin-dependent kinase 12.
Cyclin-dependent kinase 12 (CDK12)
Cyclin-dependent kinase which phosphorylates the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability.
Preferentially phosphorylates'Ser-5' in CTD repeats which are currently phosphorylated at'Ser-7', but could also phosphorylate'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2.
Gene Information
| Human | |
|---|---|
| Gene Name: | CDK12 |
| Uniprot: | Q9NYV4 |
| Entrez: | 51755 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
Cdc2-related kinase, arginine/serine-richCrkRS; Cell division cycle 2-related protein kinase 7; Cell division protein kinase 12; CRK7CDC2-related protein kinase 7; CRKR; CRKRS; cyclin-dependent kinase 12; EC 2.7.11; EC 2.7.11.23; hCDK12; KIAA0904EC 2.7.11.22
Molecular Weight
Mass (kDA):
164.155 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q12 |
| Sequence: | 17; NC_000017.11 (39461486..39567560) |
Tissue Specificity
Ubiquitously expressed.
Subcellular Localizations
Nucleus. Nucleus speckle. Colocalized with nuclear speckles throughout interphase.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Malignant Neoplasm Of Ovary
- Epithelial Ovarian Cancer
- Ovarian Neoplasm
- Neurofibromatosis 1
- Stomach Neoplasms
- Fracture Of First Cervical Vertebra
- Malignant Neoplasm Of Breast
- Tumor Progression
- Ataxia
- Aneuploidy
Pathways
- Localization
- Methylation
- Cell Cycle
- Cell Differentiation
- Rna Interference
- Protein Phosphorylation
- Glycosylation
- Regulation Of Gene Expression
- Glomerular Filtration
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CDK12
bosterbio.com/bosterbio-gene-info-cards/CDK12
References
PMID: 11683387 by Ko T.K., et al. CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles.
PMID: 19651820 by Iorns E., et al. CRK7 modifies the MAPK pathway and influences the response to endocrine therapy.