Chromodomain Y-like protein (CDYL)

Isoform 2: Chromatin reader protein that recognizes and binds histone H3 trimethylated in'Lys-9', dimethylated in'Lys- 27' and trimethylated in'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) (PubMed:19808672, PubMed:28402439). Section of multimeric repressive chromatin complexes, where it's needed for transmission and recovery of repressive histone marks, thereby preserving the epigenetic landscape (PubMed:28402439).

Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the preexisting histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes (PubMed:22009739). Acts as a corepressor for REST by facilitating histone-lysine N- methyltransferase EHMT2 recruiting and H3K9 dimethylation in REST target genes for repression (PubMed:19061646).