CDYL Antibodies

AND CDYL ELISA kits, CDYL Proteins

Many biological assays use antibodies to detect CDYL, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CDYL in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CDYL antibodies...

We validate the specificity of these antibodies to CDYL by testing them on tissues known to express CDYL positively and negatively. Browse below to find the CDYL antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CDYL Infographic by Boster Bio

All CDYL Products

Product

Figures

Specificity

Applications

Price

Anti-CDYL1 Antibody

Human

ELISA, WB

$380
Cat # A07230
100ul

CDYL (NM_170752) Human Recombinant Protein

$1249
Cat # PROTQ9Y232
20 µg

CDYL (NM_170751) Human Over-expression Lysate

Human

$628
Cat # LS009425
100 µg

CDYL Overview

Facts about Chromodomain Y-like protein.

CDYL 3D structure. Source: alphafold

Chromodomain Y-like protein (CDYL)

Isoform 2: Chromatin reader protein that recognizes and binds histone H3 trimethylated in'Lys-9', dimethylated in'Lys- 27' and trimethylated in'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) (PubMed:19808672, PubMed:28402439). Section of multimeric repressive chromatin complexes, where it's needed for transmission and recovery of repressive histone marks, thereby preserving the epigenetic landscape (PubMed:28402439).

Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the preexisting histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes (PubMed:22009739). Acts as a corepressor for REST by facilitating histone-lysine N- methyltransferase EHMT2 recruiting and H3K9 dimethylation in REST target genes for repression (PubMed:19061646).

Gene Information

Human
Gene Name:	CDYL
Uniprot:	Q9Y232
Entrez:	9425

Family

Belongs to:

No superfamily

Alternative Names

CDYL1bA620A17.2 (chromodomain protein, Y chromosome-like); CDY-like; CDY-like, autosomal; chromodomain protein, Y chromosome-like; chromodomain protein, Y-like; chromodomain Y-like protein; DKFZP586C1622; EC 2.3.1.48; MGC131936; testis-specific chromodomain Y-like protein

Molecular Weight

Mass (kDA):
66.482 kDA

Genomic Context


Human

Location:	6p25.1
Sequence:	6; NC_000006.12 (4706138..4955544)

Tissue Specificity

Ubiquitous (PubMed:19808672). Expressed at moderate levels in all tissues examined (PubMed:19808672). Isoform 2: Most abundantly expressed isoform (PubMed:19808672).

Subcellular Localizations

[Isoform 2]: Nucleus. Chromosome. Recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) on chromatin (PubMed:19808672). Multimerization is required for chromatin-binding (PubMed:19808672). Recruited to sites of DNA double strand breaks in a PARP1-dependent fashion (PubMed:29177481).