Cystatin-SN Antibodies

Cystatin-SN (CST1)

Human saliva seems to include several cysteine proteinase inhibitors which are immunologically related to cystatin S but that differ in their specificity because of amino acid sequence differences. Cystatin SN, with a pI of 7.

5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well. .

Gene Information

Human
Gene Name:	CST1
Uniprot:	P01037
Entrez:	1469

Family

Belongs to:
cystatin family

Alternative Names

CST1; cystain-SA-I; cystatin 1; cystatin SA-I; Cystatin SN; cystatin-1; cystatin-SN; Salivary cystatin-SA-1; type 2 family

Molecular Weight

Mass (kDA):
16.388 kDA

Genomic Context

Human
Location:	20p11.21
Sequence:	20; NC_000020.11 (23747553..23750937, complement)

Tissue Specificity

Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in saliva, tears, urine and seminal fluid.

Subcellular Localizations

Secreted.

Diseases

• Malignant Neoplasms
• Neoplasms
• Cell Transformation, Neoplastic
• Neoplasm Metastasis
• Malignant Tumor Of Colon
• Colorectal Cancer
• Colorectal Neoplasms
• Adrenal Hyperplasia
• Acquired Immunodeficiency Syndrome
• Stomach Neoplasms
• Periodontitis

• Malignant Neoplasm Of Breast
• Malacia
• Encephalitis
• Metastatic Malignant Neoplasm To The Bone
• Mammary Neoplasms
• Toxoplasmosis, Animal

Interacting Proteins

• SGTA

Pathways

• Pathogenesis
• Senescence
• Cell Adhesion
• Flight
• Cell Proliferation
• Cell Motility
• Cell Death
• Cellular Senescence
• Immune Response

• Proteolysis
• Invasive Growth
• Germination

PTMs

• Phosphorylation

• Cleavage

• Iodination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CST1

Best Uses Of The CST1 Marker

Optimization Tips: How To Get Better Scores at Boster Bio

Use the CST1 Marker

CST1 is a useful marker that can be used in your research. The gene encodes multiple functions including extracellular structure organization. Collagen-containing extracellular matrix, ossification. Epithelial cell proliferation. Leukocyte migration. Wnt signaling. Endopeptidase activity. It is also closely linked to cell-substrate joints, focal adhesion, Wnt signaling pathways, and endopeptidase activity.

CST1, also known by CST1, is closely related to the prognosis and treatment of patients with lung adenocarcinoma. CST1 gene mutations were associated with disease-free survival. In addition, the protein-protein interaction network revealed potential proteins binding to CST1, which led to a gene set enrichment analysis in EMT. This was confirmed by cell experiments, which showed that CST1 overexpression promoted lung adenocarcinoma cell migration, whereas knockdown of CST1 inhibited it.

CST1 expression in nasal polyps was high in patients with ECRS. This is because it interacts with a range of factors known to exacerbate ECRS. CST1 interacts with fibroblasts and Th2 cytokines. The research has many implications for clinical diagnostics and is currently being done to investigate its role in the disease process.

MeDALL, a pan European research organization, has identified CST1 to be a biomarker in airborne allergen sensitisation. CST1 may be expressed in nasal cells and could indicate severity of allergic reaction to dog allergens. It may also be a potential target in future treatment for airborne allergies. It is a great tool that can help you identify the most vulnerable children in your study.

Boster Bio: Achieving a higher score

Boster Bio scores are not easy to achieve. This is why it is important to plan carefully. The company makes antibodies with high affinity that are trusted by the research community. Its products are validated by various assays, such as western blotting or immunohistochemistry. It also offers custom mouse monoclonal antibody production and recombinant proteins expression. It also offers multiplex services such as cytokine assays.