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Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial growth by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex care by keeping testis determination and preventing feminization: represses transcription of feminine promoting genes such as FOXL2 and activates male-specific genes.
|Sequence:||9; NC_000009.12 (841647..969090)|
Testis-specific. Expressed in prostate cancer (at protein level).
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