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DMTF1 Antibodies
AND DMTF1 ELISA kits, DMTF1 Proteins
Many biological assays use antibodies to detect DMTF1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DMTF1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DMTF1 antibodies...
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DMTF1 Overview
Facts about Cyclin-D-binding Myb-like transcription factor 1.
Cyclin-D-binding Myb-like transcription factor 1 (DMTF1)
Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity).
Isoform 1 can cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1.
Gene Information
| Human | |
|---|---|
| Gene Name: | DMTF1 |
| Uniprot: | Q9Y222 |
| Entrez: | 9988 |
Family
| Belongs to: |
|---|
| DMTF1 family |
Alternative Names
cyclin D binding myb-like transcription factor 1; cyclin D-binding Myb-like protein 1; cyclin-D-binding Myb-like transcription factor 1; Cyclin-D-interacting Myb-like protein 1; DMP1FLJ76054; FLJ25188; FLJ41265; hDMP1DMTF; hDMTF1
Molecular Weight
Mass (kDA):
84.471 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q21.12 |
| Sequence: | 7; NC_000007.14 (87152361..87196332) |
Tissue Specificity
Expressed at relatively low levels in colonic mucosa, ovary, peripheral leukocytes, prostate and small intestine, and at higher levels in spleen, testis and thymus. Expressed in multiple regions of the brain and CNS including amygdala, caudate, corpus callosum, hippocampus, substantia nigra and subthalamic nucleus. Isoform 1 is the predominant isoform in monocytes, macrophages and neutrophils, isoform 2 is most strongly expressed in peripheral blood leukocytes and quiescent CD34 positive cells, and isoform 3 is expressed at low levels in all hematopoietic cell types. Expression is frequently reduced in non- small-cell lung carcinomas (NSCLC) due to hemizygous gene deletion, strongly suggesting that this locus is haploinsufficient for tumor suppression. Loss of this locus frequently occurs in tumors which retain wild-type CDKN2A/ARF and p53/TP53 loci. Hemizygous gene deletion has also been observed in leukemic blasts from patients with abnormalities of the long arm of chromosome 7.
Subcellular Localizations
Nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Lung
- Neoplasms, Experimental
- Carcinoma
- Myeloid Leukemia
- Leukemia
- Carcinogenesis
- Lymphoma
- Adenocarcinoma
- Lung Neoplasms
- Non-small Cell Lung Carcinoma
Pathways
- Cell Cycle
- Cell Cycle Arrest
- Cell Proliferation
- G1 Phase
- Ossification
- Localization
- S Phase
- Odontoblast Differentiation
- Programmed Cell Death
- Cell Development
- Dna Methylation
- Metaphase
- Methylation
PTMs
- Phosphorylation
Research Areas
- Breast Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DMTF1
bosterbio.com/bosterbio-gene-info-cards/DMTF1
References
PMID: 10095122 by Bodner S.M., et al. Cloning and chromosomal localization of the gene encoding human cyclin D-binding Myb-like protein (hDMP1).
PMID: 12917399 by Tschan M.P., et al. Alternative splicing of the human cyclin D-binding Myb-like protein (hDMP1) yields a truncated protein isoform that alters macrophage differentiation patterns.