- Table of Content
Acts as a central dissolvase of membraneless organelles during the G2-to-M transition, after the nuclear- envelope breakdown: functions by mediating phosphorylation of multiple serine and threonine residues in unstructured domains of proteins, such as SRRM1 and PCM1 (PubMed:29973724). Doesn't mediate disassembly of all membraneless organelles: disassembly of P-body and nucleolus isn't governed by DYRK3 (PubMed:29973724).
|protein kinase superfamily|
|Sequence:||1; NC_000001.11 (206635536..206655175)|
Isoform 1: Highly expressed in testis and in hematopoietic tissue such as fetal liver, and bone marrow (PubMed:10779429). Isoform 1: Predominant form in fetal liver and bone marrow (PubMed:10779429). Isoform 1: Present at low levels in heart, pancreas, lymph node and thymus (PubMed:10779429). Isoform 2: Highly expressed in testis and in hematopoietic tissue such as fetal liver, and bone marrow (PubMed:10779429). Isoform 2: Predominant form in testis. Isoform 2: Present at low levels in heart, pancreas, lymph node and thymus (PubMed:10779429).
Nucleus. Cytoplasm. Nucleus speckle. Cytoplasmic granule. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Associates with membraneless organelles in the cytoplasm and nucleus (PubMed:29973724). Shuttles between cytoplasm and stress granules (PubMed:20167603). Localized predominantly on distinct speckles distributed throughout the cytoplasm of the cell (PubMed:20167603). At low concentration, showns a homogeneous distribution throughout the cytoplasm and does not condense in speckles. During oxidative and osmotic stress, localizes to stress granules (PubMed:20167603).