DYRK2 Antibodies

AND DYRK2 ELISA kits, DYRK2 Proteins

Many biological assays use antibodies to detect DYRK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DYRK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DYRK2 antibodies...

We validate the specificity of these antibodies to DYRK2 by testing them on tissues known to express DYRK2 positively and negatively. Browse below to find the DYRK2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DYRK2 Infographic by Boster Bio

All DYRK2 Products

Product

Figures

Specificity

Applications

Price

Anti-DYRK2 Antibody

Human

ELISA, IF, ICC, WB

$449
Cat # A03498
0.1 mg

Anti-DYRK2 Antibody

Human, Mouse, Rat

IF, IHC, WB

$405
Cat # A03498-1
100ul

DYRK2 (NM_003583) Human Over-expression Lysate

Human

$628
Cat # LS008445
100 µg

DYRK2 Overview

Facts about Dual specificity tyrosine-phosphorylation-regulated kinase 2.

DYRK2 3D structure. Source: alphafold

Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2)

Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage.

Phosphorylates NFATC1, and thus inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B.

Gene Information

Human
Gene Name:	DYRK2
Uniprot:	Q92630
Entrez:	8445

Family

Belongs to:

protein kinase superfamily

Alternative Names

dual specificity tyrosine-phosphorylation-regulated kinase 2; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2; DYRK2; EC 2.7.12; EC 2.7.12.1; FLJ21217; FLJ21365

Molecular Weight

Mass (kDA):
66.652 kDA

Genomic Context


Human

Location:	12q15
Sequence:	12; NC_000012.12 (67648745..67665406)

Tissue Specificity

Testis, after the onset of spermatogenesis.

Subcellular Localizations

Cytoplasm. Nucleus. Translocates into the nucleus following DNA damage.

Diseases

Neoplasms
Malignant Neoplasms
Cell Transformation, Neoplastic
Down Syndrome
Genotoxic Stress
Esophageal Neoplasms
Adenocarcinoma
Tumor Progression
Lung Neoplasms
Malignant Neoplasm Of Stomach
Stomach Neoplasms
Lipoma
Malignant Paraganglionic Neoplasm

Carcinogenesis
Cell Invasion
Neuroblastoma
Retinoblastoma
Alzheimer's Disease
Neoplasms, Radiation-induced
Malignant Neoplasm Of Breast

Interacting Proteins

DYRK4
IKZF1
KXD1
LZTS2
SP100

WDR62
ZBTB9

Pathways

Cell Proliferation
Localization
Cell Cycle
Translation
Induction Of Apoptosis
Mitosis
Dna Repair
Cell Death
Brain Development
Cell Cycle Arrest
Cell Differentiation
Meiosis
Oncogenesis

Rna Interference
Protein Phosphorylation
Hyperphosphorylation
Meiosis Ii
Fertilization
Protein Maturation
Immune Response

PTMs

Phosphorylation
Acetylation

Methylation
Dephosphorylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DYRK2

References

PMID: 9748265 by Becker W., et al. Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases.

PMID: 11311121 by Woods Y.L., et al. The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3- priming kinase.