Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2)

Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage.

Phosphorylates NFATC1, and thus inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B.