Crossover junction endonuclease EME1 (EME1)

Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end in the branch nick. Typical substrates include 3'- flap structures, replication forks and nicked Holliday junctions.

May be required in mitosis for the processing of stalled or collapsed replication forks. .