EMP2 Antibodies

AND EMP2 ELISA kits, EMP2 Proteins

Many biological assays use antibodies to detect EMP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with EMP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop EMP2 antibodies...

We validate the specificity of these antibodies to EMP2 by testing them on tissues known to express EMP2 positively and negatively. Browse below to find the EMP2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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EMP2 Infographic by Boster Bio

All EMP2 Products

Product

Figures

Specificity

Applications

Price

EMP2 (NM_001424) Human Recombinant Protein

$1249
Cat # PROTP54851
20 µg

EMP2 (NM_001424) Human Over-expression Lysate

Human

$628
Cat # LS002013
100 µg

EMP2 Overview

Facts about Epithelial membrane protein 2.

EMP2 3D structure. Source: alphafold

Epithelial membrane protein 2 (EMP2)

Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Additionally, it plays a role in regulation of processes such as cell migration, cell proliferation, cell contraction and cell adhesion.

Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by raising lysosomal degradation (PubMed:24814193). Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins (By similarity).

Gene Information

Human
Gene Name:	EMP2
Uniprot:	P54851
Entrez:	2013

Family

Belongs to:

PMP-22/EMP/MP20 family

Alternative Names

EMP2; epithelial membrane protein 2; MGC9056; Protein XMP; XMP; XMPEMP-2

Molecular Weight

Mass (kDA):
19.199 kDA

Genomic Context


Human

Location:	16p13.13
Sequence:	16; NC_000016.10 (10528422..10580598, complement)

Tissue Specificity

Expressed in ciliary body epithelia, sclera, cornea, and retinal pigment epithelium (at protein level) (PubMed:12710941).

Subcellular Localizations

Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane. Apical cell membrane. Membrane raft. Cytoplasm. Nucleus. Localizes in cytoplasm, foot processes and cell bodies of podocytes and nucleus of endothelial cells of kidney. Localizes to the apical cell surface in the luminal epithelium and glandular epithelium. Colocalized with ITGB1 and GPI-anchor proteins on plasma membrane.

Diseases

Neoplasms
Endometrial Polyp
Malignant Neoplasms
Endometrial Carcinoma
Tissue Adhesions
Proliferative Vitreoretinopathy
Endometrial Neoplasms
Endometrial Adenocarcinoma
Carcinoma
Precancerous Conditions
Adenocarcinoma
Charcot-marie-tooth Disease

Malignant Paraganglionic Neoplasm
Nervousness
Chlamydia Infections
Lymphoma
Ovarian Neoplasm
Homogeneously Staining Region

Pathways

Cell Death
Localization
Wound Healing
Cell Proliferation
Cell Growth
Enucleation
Shoot Development
Myelination
Embryo Development
Schwann Cell Proliferation

Regeneration
Cellular Localization
Regulation Of Cell Proliferation
Secretion

PTMs

Phosphorylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EMP2

References

PMID: 8917086 by Taylor V., et al. Epithelial membrane protein-2 and epithelial membrane protein-3: two novel members of the peripheral myelin protein 22 gene family.

PMID: 8996089 by Ben-Porath I., et al. Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins.