Ectonucleoside triphosphate diphosphohydrolase 6 (ENTPD6)

Might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent, there isn't any hydrolysis of nucleoside 5'-monophosphates.

The order of activity with different substrates is GDP > IDP >> UDP = CDP >> ADP (By similarity). .