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- Table of Contents
ERCC2 Antibodies
AND ERCC2 ELISA kits, ERCC2 Proteins
Many biological assays use antibodies to detect ERCC2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ERCC2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ERCC2 antibodies...
Designing a Western blot for ERCC2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ERCC2 Western Blot GuideERCC2 Infographic by Boster Bio
All ERCC2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A00694-2
100 μg/vial
Cat # A00694-2
100 μg/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M00694-1
100 μl/vial
Cat # M00694-1
100 μl/vial
ERCC2 Overview
Facts about General transcription and DNA repair factor IIH helicase subunit XPD.
General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2)
In NER, TFIIH acts by opening DNA around the lesion to enable the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/ERCC2 is needed for DNA opening.
In transcription, TFIIH has an essential role in transcription initiation. When the pre- initiation complex (PIC) was established, TFIIH is required for promoter opening and promoter escape.
Gene Information
| Human | |
|---|---|
| Gene Name: | ERCC2 |
| Uniprot: | P18074 |
| Entrez: | 2068 |
Family
| Belongs to: |
|---|
| helicase family |
Alternative Names
Basic transcription factor 2 80 kDa subunit; BTF2 p80; COFS2; CXPD; DNA excision repair protein ERCC-2; DNA repair protein complementing XP-D cells; EC 3.6.1; EC 3.6.4.12; EM9; EM9TFIIH basal transcription factor complex 80 kDa subunit; ERCC2; excision repair cross-complementing rodent repair deficiency, complementationgroup 2; MAG; MGC102762; MGC126218; MGC126219; TFIIH 80 kDa subunit; TFIIH basal transcription factor complex helicase subunit; TFIIH basal transcription factor complex helicase XPD subunit; TTD; xeroderma pigmentosum complementary group D; Xeroderma pigmentosum group D-compleme
Molecular Weight
Mass (kDA):
86.909 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.32 |
| Sequence: | 19; NC_000019.10 (45349837..45370647, complement) |
Subcellular Localizations
Nucleus. Cytoplasm, cytoskeleton, spindle.
Diseases
- Malignant Neoplasms
- Xeroderma Pigmentosum
- Xeroderma
- Neoplasms
- Malignant Neoplasm Of Lung
- Xeroderma Pigmentosum, Group D
- Lung Neoplasms
- Carcinoma
- Trichothiodystrophy Syndromes
- Cockayne Syndrome
- Malignant Neoplasm Of Breast
- Malignant Squamous Cell Neoplasm
- Mammary Neoplasms
Interacting Proteins
- ERCC3
- GTF2H2C
- MMS19
Pathways
- Dna Repair
- Cell Cycle
- Aging
- Pathogenesis
- Hypersensitivity
- Cell Death
- Cell Proliferation
- Mismatch Repair
- Transport
- Nucleotide-excision Repair
- Drug Resistance
- Cell Growth
- Double-strand Break Repair
PTMs
- Phosphorylation
- Methylation
- Reduction
- Cleavage
Research Areas
- Cancer
- DNA Repair
- Nucleotide Excision Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ERCC2
bosterbio.com/bosterbio-gene-info-cards/ERCC2
References
PMID: 2184031 by Weber C.A., et al. ERCC2: cDNA cloning and molecular characterization of a human nucleotide excision repair gene with high homology to yeast RAD3.
PMID: 8786141 by Lamerdin J.E., et al. Sequence analysis of the ERCC2 gene regions in human, mouse, and hamster reveals three linked genes.