ERCC6L Antibodies

AND ERCC6L ELISA kits, ERCC6L Proteins

Many biological assays use antibodies to detect ERCC6L, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ERCC6L in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ERCC6L antibodies...

We validate the specificity of these antibodies to ERCC6L by testing them on tissues known to express ERCC6L positively and negatively. Browse below to find the ERCC6L antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ERCC6L Infographic by Boster Bio

All ERCC6L Products

Product

Figures

Specificity

Applications

Price

ERCC6L (NM_017669) Human Over-expression Lysate

Human

$960
Cat # LS054821
100 µg

ERCC6L Overview

Facts about DNA excision repair protein ERCC-6-like.

ERCC6L 3D structure. Source: alphafold

DNA excision repair protein ERCC-6-like (ERCC6L)

DNA helicase that serves as an important component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruitment MAD2 to kinetochores and observation tension on centromeric chromatin (PubMed:17218258).

Acts as a tension sensor that partners with catenated DNA which is stretched under tension until it is solved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671).

Gene Information

Human
Gene Name:	ERCC6L
Uniprot:	Q2NKX8
Entrez:	54821

Family

Belongs to:

SNF2/RAD54 helicase family

Alternative Names

ATP-dependent helicase ERCC6-like; DNA excision repair protein ERCC-6-like; EC 3.6.1; EC 3.6.4.12; excision repair cross-complementing rodent repair deficiency, complementationgroup 6-like; excision repair protein ERCC6-like; FLJ20105; MGC131695; PICHexcision repair cross-complementing rodent repair deficiency complementationgroup 6 - like; PLK1-interacting checkpoint helicase; SNF2/RAD54 family protein; Tumor antigen BJ-HCC-15

Molecular Weight

Mass (kDA):
141.103 kDA

Genomic Context


Human

Location:	Xq13.1
Sequence:	X; NC_000023.11 (72204665..72239027, complement)

Subcellular Localizations

Chromosome, centromere. Chromosome, centromere, kinetochore. Chromosome. Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase. In prometaphase cells, it mostly concentrates in between kinetochores. In metaphase, it localizes to numerous thin threads that stretch between sister kinetochores of the aligned chromosomes and are composed of catenated centromeric DNA. Evolution from inner centromeres to thin threads takes place in response to tension. Resolution of thin threads requires topoisomerase 2-alpha (TOP2A) after anaphase onset