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The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, a significant measure for the regulation of TGF- beta signaling, cell migration and the timing of this cell-cycle development and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity.
|Sequence:||2; NC_000002.12 (47806920..47906498, complement)|
Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.