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- Table of Contents
GLRX2 Antibodies
AND GLRX2 ELISA kits, GLRX2 Proteins
Many biological assays use antibodies to detect GLRX2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GLRX2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GLRX2 antibodies...
Designing a Western blot for GLRX2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the GLRX2 Western Blot GuideGLRX2 Infographic by Boster Bio
All GLRX2 Products
Product
Figures
Specificity
Applications
Price
Anti-Glutaredoxin 2/GLRX2 Antibody Picoband®
2 Citations
Human, Mouse, Rat
IHC, WB
$370
Cat # PA1885
100 μg/vial
Cat # PA1885
100 μg/vial
Human, Mouse
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A05331
100 μg/vial
Cat # A05331
100 μg/vial
Human
$628
Cat # LS051022
20 µg, 100 µg
Cat # LS051022
20 µg, 100 µg
GLRX2 Overview
Facts about Glutaredoxin-2, mitochondrial.
Glutaredoxin-2, mitochondrial (GLRX2)
Glutathione-dependent oxidoreductase that eases the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis due to oxidative stress.
Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions.
Gene Information
| Human | |
|---|---|
| Gene Name: | GLRX2 |
| Uniprot: | Q9NS18 |
| Entrez: | 51022 |
Family
| Belongs to: |
|---|
| glutaredoxin family |
Alternative Names
bA101E13.1 (GRX2 glutaredoxin (thioltransferase) 2); glutaredoxin 2; glutaredoxin-2, mitochondrial; GRX2bA101E13.1
Molecular Weight
Mass (kDA):
18.052 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q31.2 |
| Sequence: | 1; NC_000001.11 (193096465..193106114, complement) |
Tissue Specificity
Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta and lung. Not expressed in peripheral blood leukocytes.
Subcellular Localizations
[Isoform 1]: Mitochondrion.; [Isoform 2]: Nucleus.
Diseases
- Neoplasms
- Parkinson Disease
- Ischemia
- Heart Diseases
- Adenoma
- Brain Ischemia
- Melanoma
- Radiation Injuries, Experimental
- Spermatogenesis Arrest
- Parathyroid Neoplasms
- Testicular Injury
- Lung Diseases
- Carcinoma
Pathways
- Localization
- Cell Death
- Cell Proliferation
- Protein Deglutathionylation
- Mitochondrial Translocation
- Secretion
- Regulation Of Cell Death
- Response To Superoxide
- Osteoclast Differentiation
- Induction Of Apoptosis
- Insulin Secretion
- Brain Development
- Spermatogenesis
PTMs
- Reduction
- Glutathionylation
- Oxidation
Research Areas
- Apoptosis
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GLRX2
bosterbio.com/bosterbio-gene-info-cards/GLRX2
References
PMID: 11297543 by Lundberg M., et al. Cloning and expression of a novel human glutaredoxin (Grx2) with mitochondrial and nuclear isoforms.
PMID: 11397793 by Gladyshev V.N., et al. Identification and characterization of a new mammalian glutaredoxin (thioltransferase), Grx2.
1 Publications of Boster GLRX2 Antibodies & ELISA Kits
- PubMed ID: 10.1016/j.envint.2020.105654, Enhanced expression of nicotinamide nucleotide transhydrogenase (NNT) and its ro...
*More publications can be found for each product on its corresponding product page