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- Table of Contents
2 Citations 1 Q&As
Facts about Glutaredoxin-2, mitochondrial.
Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions.
| Human | |
|---|---|
| Gene Name: | GLRX2 |
| Uniprot: | Q9NS18 |
| Entrez: | 51022 |

| Belongs to: |
|---|
| glutaredoxin family |

bA101E13.1 (GRX2 glutaredoxin (thioltransferase) 2); glutaredoxin 2; glutaredoxin-2, mitochondrial; GRX2bA101E13.1
Mass (kDA):
18.052 kDA

| Human | |
|---|---|
| Location: | 1q31.2 |
| Sequence: | 1; NC_000001.11 (193096465..193106114, complement) |
Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta and lung. Not expressed in peripheral blood leukocytes.
[Isoform 1]: Mitochondrion.; [Isoform 2]: Nucleus.





PMID: 11297543 by Lundberg M., et al. Cloning and expression of a novel human glutaredoxin (Grx2) with mitochondrial and nuclear isoforms.
PMID: 11397793 by Gladyshev V.N., et al. Identification and characterization of a new mammalian glutaredoxin (thioltransferase), Grx2.
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