Platelet glycoprotein VI Antibodies

AND GP6 ELISA kits, Platelet glycoprotein VI Proteins

Many biological assays use antibodies to detect Platelet glycoprotein VI, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Platelet glycoprotein VI in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Platelet glycoprotein VI antibodies...

We validate the specificity of these antibodies to Platelet glycoprotein VI by testing them on tissues known to express GP6 positively and negatively. Browse below to find the GP6 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GP6 Infographic by Boster Bio

All GP6 Products

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Specificity

Applications

Price

Anti-GPVI GP6 Antibody

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A02208
0.1 mg

Glycoprotein VI (GP6) (NM_016363) Human Over-expression Lysate

Human

$628
Cat # LS051206
100 µg

Human GPVI ELISA Kit PicoKine®

Human

ELISA

$499
Cat # EK2212
96 wells/kit, with removable strips.

GP6 Overview

Facts about Platelet glycoprotein VI.

GP6 3D structure. Source: alphafold

Platelet glycoprotein VI (GP6)

Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a vital role in platelet procoagulant activity and following thrombin and fibrin formation.

This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma- chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.

Gene Information

Human
Gene Name:	GP6
Uniprot:	Q9HCN6
Entrez:	51206

Family

Belongs to:

No superfamily

Alternative Names

Glycoprotein 6; glycoprotein VI (platelet); GP6; GPIV; GPVI; GPVIplatelet collagen receptor; MGC138168; platelet glycoprotein VI

Molecular Weight

Mass (kDA):
36.866 kDA

Genomic Context


Human

Location:	19q13.42
Sequence:	19; NC_000019.10 (55013705..55038264, complement)

Tissue Specificity

Megakaryocytes and platelets.

Subcellular Localizations

[Isoform 1]: Cell membrane; Single-pass membrane protein.; [Isoform 2]: Cell membrane; Single-pass membrane protein.

Diseases

Papillomavirus Infections
Neoplasms
Uterine Cervical Neoplasm
Malignant Neoplasms
Carcinoma
Cervical Intraepithelial Neoplasia
Malignant Squamous Cell Neoplasm
Tumor Virus Infections
Malignant Tumor Of Cervix
Intraepithelial Neoplasia
Thrombosis
Adenocarcinoma

Von Willebrand Disease
Infective Disorder
Hemorrhage
Papilloma
Infarction
Tissue Adhesions
Human Papilloma Virus Infection

Interacting Proteins

Pathways

Pathogenesis
Cell Proliferation
Platelet Activation
Platelet Aggregation
Hemostasis
Virion Assembly
Dna Packaging
Hypersensitivity
Ph Reduction
Megakaryocyte Differentiation
Demethylation

Regeneration
Fermentation
Coagulation
Cell Cycle
Methanogenesis
Telomere Maintenance

PTMs

Demethylation
Phosphorylation

Biotinylation
Glycosylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GP6

References

PMID: 11027634 by Ezumi Y., et al. Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI.

PMID: 10961879 by Jandrot-Perrus M., et al. Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily.