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- Table of Contents
HERC5 Antibodies
AND HERC5 ELISA kits, HERC5 Proteins
Many biological assays use antibodies to detect HERC5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HERC5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HERC5 antibodies...
Designing a Western blot for HERC5? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the HERC5 Western Blot GuideHERC5 Infographic by Boster Bio
All HERC5 Products
Product
Figures
Specificity
Applications
Price
Anti-SEC23A Antibody Picoband®
1 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A05287-2
100 μg/vial
Cat # A05287-2
100 μg/vial
HERC5 Overview
Facts about E3 ISG15--protein ligase HERC5.
E3 ISG15--protein ligase HERC5 (HERC5)
Catalyzes ISGylation of IRF3 which leads to sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 that attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets.
Gene Information
| Human | |
|---|---|
| Gene Name: | HERC5 |
| Uniprot: | Q9UII4 |
| Entrez: | 51191 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CEB1E3 ISG15--protein ligase HERC5; CEBP1; cyclin-E binding protein 1; Cyclin-E-binding protein 1; EC 6.3.2; EC 6.3.2.-; HECT domain and RCC1-like domain-containing protein 5; hect domain and RLD 5; HECT E3 ubiquitin ligase; probable E3 ubiquitin-protein ligase HERC5
Molecular Weight
Mass (kDA):
116.852 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q22.1 |
| Sequence: | 4; NC_000004.12 (88456604..88506170) |
Tissue Specificity
Expressed in testis and to a lesser degree in brain, ovary and placenta. Found in most tissues at low levels.
Subcellular Localizations
Cytoplasm, perinuclear region. Associated with the polyribosomes, probably via the 60S subunit.
Diseases
- Influenza
- Innate Immune Response
- Hiv Infections
- Malignant Neoplasms
- Neoplasms
- Bacterial Infections
- Germline Mutation Abnormality
- Autoimmune Diseases
- Carcinogenesis
- Infective Disorder
- Virus Diseases
- Autoimmune Reaction
Pathways
- Conjugation
- Cell Cycle
- Pathogenesis
- Osteoclast Differentiation
- Cell Proliferation
- Cellular Senescence
- Immune Response
- Dna Repair
- Neuron Differentiation
- Virulence
- Localization
- Cell Cycle Arrest
PTMs
- Isgylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HERC5
bosterbio.com/bosterbio-gene-info-cards/HERC5
References
PMID: 10581175 by Mitsui K., et al. A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins.
PMID: 15331633 by Kroismayr R., et al. HERC5, a HECT E3 ubiquitin ligase tightly regulated in LPS activated endothelial cells.
1 Publications of Boster HERC5 Antibodies & ELISA Kits
- PubMed ID: 24687377, Yang F, Zhou X, Miao X, Zhang T, Hang X, Tie R, Liu N, Tian F, Wang F, Yuan J. B...
*More publications can be found for each product on its corresponding product page