Porphobilinogen deaminase Antibodies

Porphobilinogen deaminase (HMBS)

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in many discrete steps. .

Gene Information

Human
Gene Name:	HMBS
Uniprot:	P08397
Entrez:	3145

Family

Belongs to:
HMBS family

Alternative Names

hydroxymethylbilane synthasePre-uroporphyrinogen synthase; PBGDPBG-D; PORC; porphobilinogen deaminase; porphyria, acute; Chester type; UPSEC 2.5.1.61; uroporphyrinogen I synthase; uroporphyrinogen I synthetase

Molecular Weight

Mass (kDA):
39.33 kDA

Genomic Context

Human
Location:	11q23.3
Sequence:	11; NC_000011.10 (119084864..119093549)

Tissue Specificity

Isoform 1 is ubiquitously expressed. Isoform 2 is found only in erythroid cells.

Subcellular Localizations

Cytoplasm.

Diseases

• Acute Intermittent Porphyria
• Disorders Of Porphyrin Metabolism
• Acute Interstitial Pneumonia
• Neoplasms
• Malignant Neoplasms
• Porphyrias, Hepatic
• Malignant Paraganglionic Neoplasm
• Carcinoma
• Hypokinesia
• Neoplasm Metastasis
• Porphyria Cutanea Tarda
• Hereditary Coproporphyria

• Liver Neoplasms
• Variegate Porphyria
• Leukemia
• Melanoma
• Kidney Neoplasm
• Erythropoietic Protoporphyria
• Liver Carcinoma

Pathways

• Reverse Transcription
• Pathogenesis
• Localization
• Osteoblast Differentiation
• Aging
• Cytokine Secretion
• Immune Response
• Regulation Of Gene Expression
• Chromosome Segregation
• Cytokine Production

• Mrna Transcription
• Angiogenesis
• Lymphocyte Proliferation
• Excretion
• Secretion

PTMs

• Reduction

• Oxidation

Research Areas

• Diabetes Research

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HMBS

Boster Bio - Best Uses Of The HMBS Marker

If you're interested in high-affinity primary antibodies, high-affinity secondary antibodies or pasteurization methods, you're in the right spot. Boster Bio provides these to all scientists around the world. Boster scientists can publish their findings and get product credits as well. Scientists can submit data in a variety format using the HMBS Marker.

Primary antibodies that have high affinity

High-affinity primary antibodies are the most powerful and versatile type of antibody that is available for research. Their affinity increases by 10- to one-hundredfold in secondary and subsequent antibody responses. At this point B cells produce IgG and IgA antibodies. In addition the antibodies are produced by memory B cells that have changed from IgM to one of the two mature isotypes.

Steven Boster, who developed his first product in 1993, earned a reputation for being the "science convertor" in the lavatory. Boster's company had already created hundreds of primary antibodies in the mid-nineties. Utilizing their exclusive technology and methods, Boster had established itself as the largest catalog antibody manufacturer in China. The high-affinity antibodies that Boster provides are extremely sensitive and tested for IHC, WB, ELISA and flow cytometry.

In addition to high-affinity antibodies, Boster Bio also offers ELISA kits and antigens that are specialized. The high-affinity antibodies they offer are created by highly-validated, unique-made processes. They are designed for researchers and are supported by years of experience. Boster Bio is the best choice if you are looking for high-affinity antibodies that will aid in your research. They've been a major supplier of antibodies for decades.

High-affinity antibodies are necessary for performing sandwich ELISAs. To be effective, the antibody must recognize epitopes with non-overlapping epitopes. Using the same antibody for detection and capture limits the dynamic range of the ELISA since it limits the sensitiveness and dynamic range. However sandwich ELISAs can be extremely efficient using matched pairs and can be used in a variety of applications. The primary antibody manufacturer will provide detailed information about the epitopes.

Monoclonal antibodies are used as the primary immunoglobulins. It has a high affinity for a specific antigen, low cross-reactivity and a minimal lot-to-lot variation. Monoclonal antibodies are typically produced in mice to serve a variety of purposes. However, recent techniques have made it possible to create antibodies from different species. These antibodies are a perfect solution for various research purposes.

High-affinity primary antibodies can be purchased in dual-label format. Researchers are able to answer more questions by using the same specimen by using two different antibodies. This provides them with greater context and solid responses. This antibody is more effective in research, and can be used for the use of gene therapy and clinical diagnostics. Primary antibodies with high affinity are ideal for research and development. The quality of the primary antibodies will greatly enhance your research results. These antibodies allow you to analyze, purify and quantify the antigen that is of interest.

The H5-Ab1 and H5-Ab6 were used to investigate the binding affinity of various proteins to the HA subtype. Cross-reactivity was observed between h2-Ab1 (and H2) of the H5-Ab1-Ab2 as well as H5–Ab2, which confirms their ability to bind to these proteins. H3-Ab4 showed the lowest cross-reactivity compared to other antibodies. This was a positive sign that indicated a higher affinity for HA.

Pasteurization methods

Pasteurization is an ideal for extending the shelf time of food items. It eliminates enzymes and bacteria that can cause food to spoil. There are many different methods of pasteurization. Each has its own advantages. Here are some of the most popular methods of pasteurization. We'll look at the most important and how they will benefit your product. Let's get started. What is pasteurization?

Milk begins with active enzymes that block pathogen growth. Heating destroys these enzymes. It also prevents the Maillard reaction and caramelization, which can be caused by pathogens. When pasteurization is performed, milk cells are heated to a pressure of high which kills bacteria. This step is important because milk may taste sour when enzymes are active. Here are some methods that are commonly used for pasteurization.

One of the most important reasons to pasteurize is that it kills bacteria and germs that cause illness, including food poisoning and septic sore throat. Bakteries in milk can trigger illnesses like Q fever or brucellosis. Pasteurization is necessary for milk production since milk is perishable. While the process kills bacteria, it cannot completely eliminate all pathogenic microorganisms.

Another method of pasteurizing liquids is to use the use of a tube and shell heat exchanger. This method is not Newtonian, and involves raising temperatures up to 161 degrees F for 15 seconds. This treatment also extends the shelf life of refrigerated items. A third method is called ultra pasteurization, which involves heating liquids at higher temperatures than the two other methods. These methods are the most commonly employed in the United States.

Europe currently controls the purity of human milk on two levels. For instance, it needs 104 colony-forming units (CFU) of Staphyloccocus aureus before pasteurization. It is also essential to remove vegetative bacteria from milk prior to pasteurization. Using the blue milk test is not sufficient. Quality control studies should be focused on the type and the amount of bacteria in milk.

The process of pasteurization removes harmful bacteria from milk by cooling and heating the milk. Pasteurization does not alter the nutritional or taste of the milk. The process is precise, and kills bacteria. This makes milk the safest food you can eat which reduces the chance of getting sick caused by harmful bacteria. The process has some disadvantages and you need to determine which one is best for your requirements.

While the process of pasteurization is widely used, it does not sterilize all types of food. Certain bacteria are not able to respond to pasteurization. Because of this, newer techniques are being developed to treat food in such as to ensure that it's as safe as it was when it was first manufactured. These methods include extrusion, thermization, and 'cold' pasteurization. These methods will be studied in greater depth.