Porphobilinogen deaminase Antibodies

AND HMBS ELISA kits, Porphobilinogen deaminase Proteins

Many biological assays use antibodies to detect Porphobilinogen deaminase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Porphobilinogen deaminase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Porphobilinogen deaminase antibodies...

We validate the specificity of these antibodies to Porphobilinogen deaminase by testing them on tissues known to express HMBS positively and negatively. Browse below to find the HMBS antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for Porphobilinogen deaminase? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the HMBS Western Blot Guide

HMBS Infographic by Boster Bio

All HMBS Products

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Specificity

Applications

Price

Anti-HMBS Antibody Picoband®

Western blot analysis of HMBS using anti-HMBS antibody (A01506-1)

Human, Mouse, Rat

ELISA, WB

$370
Cat # A01506-1
100 μg/vial

Anti-HMBS Rabbit Monoclonal Antibody

Western blot analysis of HMBS expression in HepG2 cell lysate

Human, Mouse, Rat

$370
Cat # M01506
100 μl

HMBS (NM_000190) Human Over-expression Lysate

HMBS Human Over-expression Lysates NM_000190

Human

$628
Cat # LS003145
20 µg, 100 µg

Human HMBS Recombinant Protein

SDS-PAGE

$250
Cat # PROTP08397
Starting from 20ug

HMBS Overview

Facts about Porphobilinogen deaminase.

HMBS 3D structure. Source: alphafold

Porphobilinogen deaminase (HMBS)

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in many discrete steps. .

Gene Information

Human
Gene Name:	HMBS
Uniprot:	P08397
Entrez:	3145

Family

Belongs to:

HMBS family

Alternative Names

hydroxymethylbilane synthasePre-uroporphyrinogen synthase; PBGDPBG-D; PORC; porphobilinogen deaminase; porphyria, acute; Chester type; UPSEC 2.5.1.61; uroporphyrinogen I synthase; uroporphyrinogen I synthetase

Molecular Weight

Mass (kDA):
39.33 kDA

Genomic Context


Human

Location:	11q23.3
Sequence:	11; NC_000011.10 (119084864..119093549)

Tissue Specificity

Isoform 1 is ubiquitously expressed. Isoform 2 is found only in erythroid cells.

Subcellular Localizations

Cytoplasm.

Diseases

Acute Intermittent Porphyria
Disorders Of Porphyrin Metabolism
Acute Interstitial Pneumonia
Neoplasms
Malignant Neoplasms
Porphyrias, Hepatic
Malignant Paraganglionic Neoplasm
Carcinoma
Hypokinesia
Neoplasm Metastasis
Porphyria Cutanea Tarda
Hereditary Coproporphyria

Liver Neoplasms
Variegate Porphyria
Leukemia
Melanoma
Kidney Neoplasm
Erythropoietic Protoporphyria
Liver Carcinoma

Pathways

Reverse Transcription
Pathogenesis
Localization
Osteoblast Differentiation
Aging
Cytokine Secretion
Immune Response
Regulation Of Gene Expression
Chromosome Segregation
Cytokine Production

Mrna Transcription
Angiogenesis
Lymphocyte Proliferation
Excretion
Secretion

PTMs

Reduction

Oxidation

Research Areas

Diabetes Research

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HMBS

References

PMID: 2875434 by Raich N., et al. Molecular cloning and complete primary sequence of human erythrocyte porphobilinogen deaminase.

PMID: 3816774 by Grandchamp B., et al. Tissue-specific expression of porphobilinogen deaminase. Two isoenzymes from a single gene.