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- Table of Contents
Facts about Protein JTB.
Might be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring proper chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly.
Human | |
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Gene Name: | JTB |
Uniprot: | O76095 |
Entrez: | 10899 |
Belongs to: |
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JTB family |
Gm622; hJT; HJTB; HSPC222; JTB; Jumping translocation breakpoint protein; jumping translocation breakpoint; PAR Protein; PAR; Prostate androgen-regulated protein; protein JTB
Mass (kDA):
16.358 kDA
Human | |
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Location: | 1q21.3 |
Sequence: | 1; NC_000001.11 (153974269..153977674, complement) |
Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts.
Membrane; Single-pass type I membrane protein. Mitochondrion. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.
PMID: 10321732 by Hatakeyama S., et al. JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation.
PMID: 10762645 by Platica O., et al. PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells.