Kelch-like protein 40 Antibodies

AND Klhl40 ELISA kits, Kelch-like protein 40 Proteins

Many biological assays use antibodies to detect Kelch-like protein 40, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Kelch-like protein 40 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Kelch-like protein 40 antibodies...

We validate the specificity of these antibodies to Kelch-like protein 40 by testing them on tissues known to express Klhl40 positively and negatively. Browse below to find the Klhl40 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Klhl40 Infographic by Boster Bio

All Klhl40 Products

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Applications

Price

KBTBD5 (KLHL40) (NM_152393) Human Over-expression Lysate

Human

$960
Cat # LS131377
100 µg

Klhl40 Overview

Facts about Kelch-like protein 40.

Kelch-like protein 40 (Klhl40)

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a crucial regulator of skeletal muscle development (PubMed:25940086). The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex (PubMed:25940086).

Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process where it negatively regulates ubiquitination of LMOD3 is however unclear (PubMed:24960163). .

Gene Information

Mouse
Gene Name:	Klhl40
Uniprot:	Q9D783
Entrez:	72330

Family

Belongs to:

KLHL40 family

Alternative Names

Kelch-like protein 40

Molecular Weight

Mass (kDA):
69.589 kDA

Genomic Context


Mouse

Location:	9\|9 F4
Sequence:	9;

Tissue Specificity

Specifically expressed in skeletal muscles in embryonic, neonatal and adults (PubMed:24960163, PubMed:25940086). Expressed in various types of muscles, including extensor digitorum longus, gastrocnemius, soleus, diaphragm, masseter and heart (at protein level). Not detected in brain, liver and lung (at protein level).

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Klhl40

References

PMID: 23746549 by Ravenscroft G., et al. Mutations in KLHL40 are a frequent cause of severe autosomal- recessive nemaline myopathy.

PMID: 24361185 by Bowlin K.M., et al. Kbtbd5 is regulated by MyoD and restricted to the myogenic lineage.