Laminin subunit beta-1 Antibodies

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex.

It is probably required for the integrity of the cellar membrane/glia limitans that functions as an anchor point to the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, in which they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface.