LIM and cysteine-rich domains protein 1 (LMCD1)

Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, leading to repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue- specific promoters.

Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a crucial role in the progression of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.