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- Table of Contents
Facts about Protein mago nashi homolog.
The EJC marks the place of this exon-exon junction in the mature mRNA for the gene expression machinery and the core elements remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP- bound EJC core onto spliced mRNA in a stable conformation.
Human | |
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Gene Name: | MAGOH |
Uniprot: | P61326 |
Entrez: | 4116 |
Belongs to: |
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mago nashi family |
MAGOHAMAGOH1; mago-nashi (Drosophila) homolog, proliferation-associated; mago-nashi homolog, proliferation-associated (Drosophila); protein mago nashi homolog
Mass (kDA):
17.164 kDA
Human | |
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Location: | 1p32.3 |
Sequence: | 1; NC_000001.11 (53226900..53238518, complement) |
Ubiquitous.
Nucleus. Nucleus speckle. Cytoplasm. Detected in granule-like structures in the dendroplasm (By similarity). Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles (PubMed:19324961).
PMID: 9479507 by Zhao X.F., et al. The mammalian homologue of mago nashi encodes a serum-inducible protein.
PMID: 10662555 by Zhao X.F., et al. MAGOH interacts with a novel RNA-binding protein.