Protein mago nashi homolog (MAGOH)

Core part of this splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure comprising core proteins and lots of peripheral nuclear and cytoplasmic related things that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.

The EJC marks the place of this exon-exon junction in the mature mRNA for the gene expression machinery and the core elements remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP- bound EJC core onto spliced mRNA in a stable conformation.