Proto-oncogene Mas Antibodies

AND MAS1 ELISA kits, Proto-oncogene Mas Proteins

Many biological assays use antibodies to detect Proto-oncogene Mas, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Proto-oncogene Mas in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Proto-oncogene Mas antibodies...

We validate the specificity of these antibodies to Proto-oncogene Mas by testing them on tissues known to express MAS1 positively and negatively. Browse below to find the MAS1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MAS1 Infographic by Boster Bio

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MAS1 Overview

Facts about Proto-oncogene Mas.

MAS1 3D structure. Source: alphafold

Proto-oncogene Mas (MAS1)

Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), even though it up-regulates AGTR1 receptor levels.

Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is most likely due to AGTR1 being physically changed by MAS1.

Gene Information

Human
Gene Name:	MAS1
Uniprot:	P04201
Entrez:	4142

Family

Belongs to:

G-protein coupled receptor 1 family

Alternative Names

Mas; MAS1 oncogene; MAS1; MGC119966; proto-oncogene Mas

Molecular Weight

Mass (kDA):
37.465 kDA

Genomic Context


Human

Location:	6q25.3
Sequence:	6; NC_000006.12 (159890988..159917447)

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

Neoplasms
Cell Transformation, Neoplastic
Malignant Neoplasms
Pain
Malignant Paraganglionic Neoplasm
Plant Tumors
Cell Invasion
Abnormal Behavior
Essential Hypertension
Melanoma
Neoplasms, Experimental
Endoplasmic Reticulum Stress

Dysplasia
Fibrosis
Tumor Angiogenesis
Myocarditis
Mccune-albright Syndrome
Retinal Diseases
Pathologic Vasoconstriction

Pathways

Localization
Transport
Vasodilation
Translation
Protein Import
Secretion
Gene Silencing
Protein Secretion
Methylation

Cell Death
Angiogenesis
Vasoconstriction
Rna Interference

PTMs

Cleavage

Phosphorylation

Research Areas

GPCR
Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAS1

References

PMID: 3708691 by Young D., et al. Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains.

PMID: 3419518 by Jackson T.R., et al. The mas oncogene encodes an angiotensin receptor.