DNA replication licensing factor MCM3 (MCM3)

Acts as component of the MCM2-7 complicated (MCM complex) which is the putative replicative helicase essential for'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase websites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such a crucial structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.

The six ATPase active sites, however, are likely to contribute differentially to the intricate helicase activity. Required for DNA replication and cell proliferation.