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MRTFA Antibodies
AND MRTFA ELISA kits, MRTFA Proteins
Many biological assays use antibodies to detect MRTFA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MRTFA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MRTFA antibodies...
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MRTFA Overview
Facts about Myocardin-related transcription factor A.
Myocardin-related transcription factor A (MRTFA)
Transcription coactivator that partners with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics.
MRTFA binds G-actin through its RPEL repeats, regulating activity of the MRTFA-SRF complicated. Activity is also controlled by filamentous actin (F-actin) in the nucleus.
Gene Information
| Human | |
|---|---|
| Gene Name: | MRTFA |
| Uniprot: | Q969V6 |
| Entrez: | 57591 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
AMKL; KIAA1438; MALSAP and coiled-coil domain; megakaryoblastic leukemia (translocation) 1; Megakaryoblastic leukemia 1 protein; Megakaryocytic acute leukemia protein; MKL/myocardin-like protein 1; Myocardin-related transcription factor A; RNA-binding motif protein 15/megakaryoblastic leukemia-1 fusion protein
Molecular Weight
Mass (kDA):
98.919 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q13.1-q13.2 |
| Sequence: | 22; NC_000022.11 (40410289..40636719, complement) |
Tissue Specificity
Ubiquitously expressed, has been detected in lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, muscle, heart and brain.
Subcellular Localizations
Cytoplasm. Nucleus. Subcellular location is tightly regulated by actin both in cytoplasm and nucleus: high levels of G-actin in the nucleus observed during serum deprivation lead to low levels of nuclear MRTFA, while reduced levels of nuclear G-actin result in accumulation of MRTFA in the nucleus (By similarity). G-actin-binding in the cytoplasm inhibits nuclear import by masking the nuclear localization signal (NLS) (By similarity). In contrast, binding to nuclear globular actin (G-actin) promotes nuclear export to the cytoplasm (By similarity). Nuclear localization is regulated by MICAL2, wh
Diseases
- Leukemia
- Acute Megakaryocytic Leukemias
- Malignant Neoplasms
- Neoplasms
- Fibrosis
- Cell Invasion
- Tissue Adhesions
- Hypertrophy
- Neoplasm Metastasis
- Acute Leukemia
- Vascular Diseases
- Cardiac Hypertrophy
Interacting Proteins
- SRF
Pathways
- Localization
- Cell Migration
- Cell Differentiation
- Pathogenesis
- Nuclear Import
- Nuclear Export
- Muscle Cell Differentiation
- Cell Proliferation
- Cell Growth
- Chromatin Organization
- Milk Ejection
- Smooth Muscle Cell Differentiation
- Platelet Formation
PTMs
- Phosphorylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MRTFA
bosterbio.com/bosterbio-gene-info-cards/MRTFA
References
PMID: 11431691 by Ma Z., et al. Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia.
PMID: 11344311 by Mercher T., et al. Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia.