Nuclear receptor subfamily 2 group E member 1 (NR2E1)

Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation.

Involved in the regulation of retinal development and necessary for vision. During retinogenesis, modulates PTEN-Cyclin D expression through binding to the promoter region of PTEN and suppressing its activity (By similarity).