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- Table of Contents
Facts about Nuclear receptor subfamily 2 group E member 1.
Involved in the regulation of retinal development and necessary for vision. During retinogenesis, modulates PTEN-Cyclin D expression through binding to the promoter region of PTEN and suppressing its activity (By similarity).
Human | |
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Gene Name: | NR2E1 |
Uniprot: | Q9Y466 |
Entrez: | 7101 |
Belongs to: |
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nuclear hormone receptor family |
hTll; NR2E1; nuclear receptor subfamily 2, group E, member 1; Nuclear receptor TLX; Protein tailless homolog; tailes-related receptor; tailless homolog; TLL; TLX; TLXnuclear receptor subfamily 2 group E member 1; XTLL
Mass (kDA):
42.589 kDA
Human | |
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Location: | 6q21 |
Sequence: | 6; NC_000006.12 (108166022..108188809) |
Brain specific. Present in all brain sections tested, highest levels in the caudate nucleus and hippocampus, weakest levels in the thalamus.
Nucleus.
PMID: 9628820 by Jackson A., et al. The human homologue of the Drosophila tailless gene (TLX): characterization and mapping to a region of common deletion in human lymphoid leukemia on chromosome 6q21.
PMID: 11073974 by Kobayashi M., et al. Cell-type-specific regulation of the retinoic acid receptor mediated by the orphan nuclear receptor TLX.