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- Table of Contents
OAZ1 Antibodies
AND OAZ1 ELISA kits, OAZ1 Proteins
Many biological assays use antibodies to detect OAZ1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with OAZ1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop OAZ1 antibodies...
Designing an IHC experiment for OAZ1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the OAZ1 IHC GuideOAZ1 Infographic by Boster Bio
All OAZ1 Products
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OAZ1 Overview
Facts about Ornithine decarboxylase antizyme 1.
Ornithine decarboxylase antizyme 1 (OAZ1)
Ornithine decarboxylase (ODC) antizyme protein which negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (PubMed:17900240, PubMed:26305948, PubMed:26443277).
Triggers ODC degradation by causing the exposure of a cryptic proteasome-interacting surface of ODC (PubMed:26305948). Stabilizes AZIN2 by interfering with its ubiquitination (PubMed:17900240).
Gene Information
| Human | |
|---|---|
| Gene Name: | OAZ1 |
| Uniprot: | P54368 |
| Entrez: | 4946 |
Family
| Belongs to: |
|---|
| ODC antizyme family |
Alternative Names
antizyme 1; AZI; MGC138338; OAZ; ODC-Az; ornithine decarboxylase antizyme 1
Molecular Weight
Mass (kDA):
25.406 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.3 |
| Sequence: | 19; NC_000019.10 (2269486..2273488) |
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Mouth Neoplasms
- Malignant Neoplasm Of Breast
- Carcinogenesis
- Malignant Neoplasm Of Mouth
- Malignant Squamous Cell Neoplasm
- Lung Neoplasms
- Coronary Heart Disease
- Brain Ischemia
- Premature Aging Syndrome
Interacting Proteins
- AGTR1
Pathways
- Translation
- Dna Methylation
- Proteolysis
- Spermatogenesis
- Translational Frameshifting
- Methylation
- Cell Differentiation
- Cell Adhesion
- Egg Activation
- Cell Proliferation
- Dna Hypomethylation
- Cellular Senescence
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/OAZ1
bosterbio.com/bosterbio-gene-info-cards/OAZ1
References
PMID: 7811704 by Tewari D.S., et al. Molecular cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme.
PMID: 9132164 by Yang D., et al. Molecular cloning of human antizyme cDNA.