P4HB Antibodies

Protein disulfide-isomerase (P4HB)

This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to serve as a reductase which cleaves disulfide bonds of proteins attached to the cell.

May therefore cause structural modifications of exofacial proteins. Within the cell, seems to form/rearrange disulfide bonds of nascent proteins.

Gene Information

Human
Gene Name:	P4HB
Uniprot:	P07237
Entrez:	5034

Family

Belongs to:
protein disulfide isomerase family

Alternative Names

Cellular thyroid hormone-binding protein; collagen prolyl 4-hydroxylase beta; DSI; ERBA2L; GIT; glutathione-insulin transhydrogenase; P4HB; P4Hbeta; p55; PDI; PDIA1; PDIA1procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), betapolypeptide (protein disulfide isomerase-associated 1); PDIEC 5.3.4.1; PHDB; PO4DB; PO4HB; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), betapolypeptide; PROHB; PROHBprocollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), betapolypeptide (protein disulfide isomerase; thyroid hormone binding protein p5

Molecular Weight

Mass (kDA):
57.116 kDA

Genomic Context

Human
Location:	17q25.3
Sequence:	17; NC_000017.11 (81843159..81860535, complement)

Subcellular Localizations

Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome. Cell membrane; Peripheral membrane protein. Highly abundant. In some cell types, seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources (Probable). Localizes near CD4-enriched regions on lymphoid cell surfaces (PubMed:11181151). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:10636893). Colocalizes with MTTP in the endoplasmic reticulum (PubMed:23475612).

Diseases

• Polyendocrinopathies, Autoimmune
• Malignant Neoplasms
• Neoplasms
• Neurofibromatosis 1
• Inflammation
• Hypoxia
• Neoplasm Metastasis
• Melanoma
• Fibrosis
• Tumor Angiogenesis
• Tissue Adhesions
• Radiation Injury

• Stomach Neoplasms
• Burkitt Lymphoma
• Mutation, Out-of-frame
• Malignant Neoplasm Of Breast
• Ataxia
• Neoplasm Invasiveness
• Carcinoma

Interacting Proteins

• ERO1A
• HM13
• PRDX4
• TAP1

Pathways

• Cell Proliferation
• Cell Death
• Tissue Development
• Localization
• Cell Cycle
• Response To Hypoxia
• Methylation
• Angiogenesis
• Glycolysis
• Cell Migration
• Meiosis Ii
• Fertilization
• Spermatogenesis

• Reverse Transcription
• Translation
• Embryo Implantation
• Meiosis
• Transdifferentiation
• Glycosylation
• Cell-matrix Adhesion

PTMs

• Phosphorylation
• Hydroxylation
• Glycosylation

• Cleavage
• Methylation
• Oxidation

• Ubiquitination

Research Areas

• Cellular Markers
• ER Markers
• Fibroblast Cell Markers
• Hypoxia

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/P4HB

Boster Bio: Best Uses Of The P4HB Marker

The P4HB Marker is a unique biomarker that helps researchers identify the presence of PDI proteins. It can be used in species and application studies. Boster scientists can submit results for product credits and special samples. The product credits are available for all scientists worldwide. Boster scientists can also submit results for special samples for applications or species studies. These benefits are available to all scientists, and they apply to researchers of all disciplines and sizes.

Anti-PDI P4HB Marker

The Boster Bio Anti-PDI P4HB Marker is a monoclonal antibody conjugated to PE that reacts with Human, Mouse, Rat, and rat PDI proteins. The P4HB protein is a promising target for chemotherapy in ovarian cancer. It has several potential functions, including regulating cell proliferation and growth. However, its exact molecular mechanism is not well understood.

The anti-PDI P4HB marker was designed to detect the beta subunit of prolyl 4-hydroxylase, also known as P4HB. This highly abundant multifunctional enzyme is a member of the PDI family and is involved in the hydroxylation of prolyl residues in preprocollagen. It contains two thioredoxin domains that catalyze the formation and breaking of disulfide bonds.

The peptide P4HB is found in gastric tissue, where it functions as a beta subunit of the prolyl 4-hydroxylase (PDI) enzyme. It is a tetramer that forms a tetramer with P4HA1 and P4HA2. It is not clear how these two proteins interact, but both have been implicated in the development of cancer and in the progression of various types of disease. In head and neck squamous cell carcinoma (HNSCC), P4HB expression has been found to be a significant predictor of outcome.

The Boster Bio Anti-PDI P4HB marker is a novel blood test for patients with advanced or metastatic GC. In addition to detecting tumors, it also provides information about the patient's treatment and prognosis. Researchers have confirmed that the Boster Bio Anti-PDI P4HB Marker provides accurate results. In addition, the P4HB marker correlates with the TNM stage of the disease, which is an important prognostic factor for patients.

C2C1

If you are in the market for a new bacterial marker, you may want to check out the Boster Bio: P4HB. This marker enables you to detect and distinguish several types of bacteria. The different types include the Lactobacillus acidoterrestris ATCC 49025, Desulfonatronum thiodismutans strain MLF-1, Opitutaceae bacterium TAV5, and the Lachnospiraceae bacterium Paludibacter propionicigenes WB4.

The P4HB marker is used for a variety of applications, including research and development. The P4HB protein is derived from Eubacterium eligens and is used to detect various bacterial species. Boster Bio Anti-PDI P4HB Marker reacts with the protein from these bacteria and a variety of other organisms. It can be used in various research settings and is applicable to scientists around the world.

C2C2

If you're interested in determining if a food product contains Listeria, you should check the label to make sure it's safe to consume. The P4HB Marker is a unique and highly useful biomarker that can be used to identify potentially harmful bacteria in food. This marker is compatible with various strains of bacteria, including the Lactobacillus acidoterrestris ATCC 49025, Desulfonatronum thiodismutans MLF-1, Opitutaceae TAV5, and Bacillus thermoamylovorans B4166.

Boster Bio: Best Uses Of The PDI P4HB Marker is a proprietary ELISA kit. This P4HB monoclonal antibody reacts with Human, Mouse, Rat, and PDI. P4HB is a highly specific marker for secretory inflammatory phenotype and has excellent intracellular staining properties. The P4HB marker has been validated in many different cell lines and tissues, including breast, liver, and pancreatic cancer.

When assessing atherosclerotic plaques, it is important to understand which type of tissue contains P4HB. A synthetic phenotype is difficult to assess because of the extracellular staining pattern associated with deposited matrix products. This makes it necessary to investigate a specific protein, such as P4HB, to better understand the phenotype of these cells.

The P4HB gene is one of several KIRC-related biomarkers. P4HB is related to GABRAPL1, and both biomarkers are highly discriminating. The AUC (area under the curve) for each gene was calculated according to expression levels reported in the TCGA dataset. The AUC was 0.9 for both genes with an p value of 0.0001.

In addition to this, the P4HB gene is also associated with TNM staging in gastric cancer and peritoneum cavity metastasis. This gene is an independent prognostic biomarker of unfavorable OS among KIRC patients. The P4HB gene is an important marker to use for KIRC patients. So, if you are a physician, check your patient's P4HB mRNA levels to determine if this biomarker is right for you.