PCGF3 Antibodies

AND PCGF3 ELISA kits, PCGF3 Proteins

Many biological assays use antibodies to detect PCGF3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PCGF3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PCGF3 antibodies...

We validate the specificity of these antibodies to PCGF3 by testing them on tissues known to express PCGF3 positively and negatively. Browse below to find the PCGF3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PCGF3 Infographic by Boster Bio

All PCGF3 Products

Product

Figures

Specificity

Applications

Price

Anti-PCGF3 Antibody

Human, Mouse, Rat

$405
Cat # A14425
100ul

PCGF3 (NM_006315) Human Over-expression Lysate

Human

$628
Cat # LS010336
100 µg

PCGF3 Overview

Facts about Polycomb group RING finger protein 3.

PCGF3 3D structure. Source: alphafold

Polycomb group RING finger protein 3 (PCGF3)

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class necessary to maintain the transcriptionally repressive state of many genes, such as Hox genes, throughout evolution. PcG PRC1 complex acts through chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A'Lys-119', rendering chromatin heritably changed in its expressibility.

Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A'Lys-119' on the X chromosome and is required for normal silencing of a single copy of the X chromosome in XX females (By similarity).

Gene Information

Human
Gene Name:	PCGF3
Uniprot:	Q3KNV8
Entrez:	10336

Family

Belongs to:

No superfamily

Alternative Names

DKFZp686D20235; DONG1; FLJ36550; FLJ43813; MGC129615; MGC40413; polycomb group ring finger 3; polycomb group RING finger protein 3; ring finger protein 3; RNF3; RNF3ARING finger protein 3A

Molecular Weight

Mass (kDA):
28.115 kDA

Genomic Context


Human

Location:	4p16.3
Sequence:	4; NC_000004.12 (705832..770980)

Subcellular Localizations

Nucleus. Nucleus, nucleoplasm. Recruited by the non-coding RNA Xist to specific nuclear foci that probably correspond to the inactivated X chromosome.

Interacting Proteins

CBX6
CBX7
CBX8
PHC2
RING1

RNF2

Research Areas

Zinc Finger

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PCGF3

References

PMID: 21282530 by Vandamme J., et al. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells.

PMID: 26151332 by Taherbhoy A.M., et al. BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase.